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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Both ethanol toxicity and thiamine deficiency are necessary to produce long-term memory deficits in the young chick.
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Both ethanol toxicity and thiamine deficiency are necessary to produce long-term memory deficits in the young chick.

机译：乙醇毒性和硫胺素缺乏都是产生雏鸡长期记忆缺陷所必需的。

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This series of studies revealed that a 2.5-mg dose of oxythiamine administered over 2 days yielded memory deficits from 10 min following passive avoidance learning. This result existed in association with slowing of righting reflex. Administration of thiamine reversed the memory deficit and the slowing of the righting reflex. A combination of oxythiamine and peripheral alcohol administration also resulted in memory deficits appearing from 10 min after training; however, in contrast to the effect of thiamine deficiency alone, the deficits induced by thiamine deficiency in association with acute administration of alcohol could not be reversed by thiamine resupplementation. The combination of alcohol and oxythiamine also slowed the righting reflex, but higher doses of thiamine also were unable to ameliorate the memory deficit caused by a combination of oxythiamine and alcohol; however, the slowing of righting reflex was reversed. The results suggest that preexistent thiamine deficiency may make the subject susceptible to the neurotoxicological effects of alcohol on memory function.
机译：这一系列的研究表明，在被动回避学习后的10分钟内，在2天内服用2.5 mg的羟乙硫胺会产生记忆障碍。该结果与扶正反射减慢有关。硫胺素的施用可以逆转记忆力不足和扶正反射的减慢。羟乙硫胺胺和周围酒精的联合给药也会导致训练后10分钟出现记忆力减退。然而，与单独的硫胺素缺乏症的作用相反，硫胺素补充不足不能逆转由硫胺素缺乏症引起的与急性饮酒有关的缺乏症。酒精和氧硫胺素的组合也减慢了翻正反射，但高剂量的硫胺素也不能改善由氧硫胺素和酒精的组合引起的记忆障碍。然而，扶正反射的减慢被逆转了。结果表明，先前存在的硫胺素缺乏症可能使受试者容易受到酒精对记忆功能的神经毒理学影响。

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