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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Neuronal responses to systemic nicotine in the solitary tract nucleus: origin and possible relation with nutritional effects of nicotine.
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Neuronal responses to systemic nicotine in the solitary tract nucleus: origin and possible relation with nutritional effects of nicotine.

机译：对孤立道核中系统烟碱的神经元反应：烟碱的起源及其与营养作用的可能关系。

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摘要

Single-unit activity was recorded extracellularly in the caudal part of the solitary tract nucleus of anesthetized rats. Of 60 recorded neurons, 44 (73.3%) responded to intravenous (I.V.) nicotine. The incidence of response was significantly greater in the cells sensitive to moderate changes in blood glucose level, suggesting that the effects of nicotine on food intake and body weight are partly mediated by the glycemia-sensitive neurons in the caudal nucleus tractus solitarius. Only one-fourth of the neurons affected by I.V. nicotine responded in the same direction to iontophoretic nicotine application, suggesting that sensitivity to systemic nicotine results mainly from an indirect mechanism. Based on the observed effects of nicotinic agonists and antagonists unable to cross the blood-brain barrier, a majority of indirect unit responses to I.V. nicotine might be mediated by peripheral receptors, while the remaining ones might involve central or both central and peripheral receptors.
机译：在麻醉大鼠的孤立道核的尾部细胞外记录了单单位活性。在记录的60个神经元中，有44个（73.3％）对静脉内（I.V.）尼古丁有反应。在对血糖水平适度变化敏感的细胞中，反应的发生率显着更高，这表明尼古丁对食物摄入和体重的影响部分地由孤尾尾束中对血糖敏感的神经元介导。受IV影响的神经元中只有四分之一尼古丁对离子电渗疗法尼古丁的应用具有相同的响应，这表明对全身性尼古丁的敏感性主要来自间接机制。根据观察到的不能通过血脑屏障的烟碱激动剂和拮抗剂的作用，大多数间接单位对IV的反应。尼古丁可能由周围受体介导，而其余的可能涉及中枢或中枢和外周受体。

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