• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of methylphenidate on oxytocin and vasopressin levels in pinealectomized rats during light-dark cycle.
【24h】

Effects of methylphenidate on oxytocin and vasopressin levels in pinealectomized rats during light-dark cycle.

机译：哌醋甲酯对在明暗循环期间松果体切除的大鼠催产素和血管加压素水平的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although previous reports have shown that methylphenidate (MPH), in addition to its known behavioral effect, can influence the hypothalamo-pituitary-adrenal axis by increasing the plasma ACTH, the pineal gland seems to be involved in neuroendocrinological processes too, e.g., in hypothalamic synthesis and release of oxytocin (OXY) and vasopressin (AVP). Therefore, a study was performed to measure the OXY and AVP content of the hypothalamus, neurohypophysis, and plasma after application of MPH in the morning and evening in pinealectomized (PE) as well as sham-operated control (SO) rats. Pinealectomy influenced both the daily pattern (reversed in the neurohypophysis) and the levels of OXY and AVP. Starting from this different situation, application of MPH produced diverse effects. Hypothalamus: PE, increase in both hormones in the morning and evening; SO, decrease in morning OXY level. Neurohypophysis: PE, increase in morning OXY level; SO, decrease in both hormones even though in the morning only. Plasma: PE, decrease in morning OXY concentration; SO, increase in both hormones in the morning and decrease in the evening. The present results indicate that MPH application influences the hypothalamo-neurohypophysial system. Furthermore, the hypothesis has been supported that this influence may be dependent on the circadian activity of the pineal gland as well.
机译：尽管以前的报告表明，哌醋甲酯（MPH）除了具有已知的行为作用外，还可以通过增加血浆ACTH来影响下丘脑-垂体-肾上腺轴，但松果体似乎也参与了神经内分泌过程，例如在下丘脑催产素（OXY）和加压素（AVP）的合成和释放。因此，进行了一项研究，以在松果体切除（PE）以及假手术对照（SO）大鼠中，在早晨和傍晚使用MPH后测量下丘脑，神经垂体和血浆的OXY和AVP含量。松果切除术影响了每日模式（在神经垂体中逆转）以及OXY和AVP的水平。从这种不同的情况开始，MPH的应用产生了多种效果。下丘脑：PE，在早晚两种激素都增加;因此，降低早晨的OXY水平。神经垂体：PE，早晨OXY水平升高;因此，即使只是在早上，两种激素的含量也要减少。血浆：PE，早晨OXY浓度降低;因此，早上两种激素都增加，晚上则减少。目前的结果表明，MPH的使用会影响下丘脑-神经垂体系统。此外，这一假说已经得到支持，该影响也可能取决于松果体的昼夜节律活动。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号