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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Involvement of opioid mu 1 receptors in morphine-induced conditioned place preference in rats.
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Involvement of opioid mu 1 receptors in morphine-induced conditioned place preference in rats.

机译：阿片样物质mu 1受体参与吗啡诱导的大鼠条件性位置偏爱。

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The main purpose of this study was to evaluate the role of mu 1-opioid receptors in morphine reward. Therefore, we studied the ability of a mu 1-selective antagonist, naloxonazine [15 mg/kg intraperitoneally (IP)], to antagonize the conditioned place preference (CPP) induced by morphine [3 mg/kg subcutaneously (SC)]. In addition, effects of naloxonazine on morphine-induced catalepsy (15 mg/kg), analgesia (3 mg/kg), and hyperthermia (3 mg/kg) were studied. For comparison, the effects of a nonselective opioid receptor antagonist, naltrexone (2.5 mg/kg SC), and a selective delta-opioid receptor antagonist, naltrindole (2 mg/kg IP), on CPP induced by morphine were investigated. Morphine-induced CPP was clearly antagonized by pretreatment with naloxonazine and naltrexone (12 h and 20 min prior to morphine, respectively) but not by naltrindole (15 min before morphine). Naloxonazine also antagonized morphine-induced catalepsy and analgesia but not morphine-induced hyperthermia. Naltrindole did not modify morphine-induced catalepsy. These results suggest an active role for mu 1-opioid receptors in morphine reward, whereas morphine-induced hyperthermia does not appear to be mediated by mu 1-opioid receptors. Furthermore, delta-opioid receptors seem to be without significance in morphine-induced reward.
机译：这项研究的主要目的是评估μ1阿片受体在吗啡奖励中的作用。因此，我们研究了mu 1选择性拮抗剂纳洛酮嗪[15 mg / kg腹膜内（IP）]拮抗吗啡[3 mg / kg皮下（SC）]诱导的条件性位置偏爱（CPP）的能力。此外，研究了纳洛嗪对吗啡引起的僵直症（15 mg / kg），镇痛（3 mg / kg）和热疗（3 mg / kg）的影响。为了进行比较，研究了非选择性阿片受体拮抗剂纳曲酮（2.5 mg / kg SC）和选择性δ-阿片受体拮抗剂纳曲酮（2 mg / kg IP）对吗啡诱导的CPP的影响。吗啡诱导的CPP明显被纳洛酮嗪和纳曲酮预处理（分别在吗啡之前12小时和20分钟）拮抗，但未被纳曲酮（吗啡之前15分钟）拮抗。纳洛酮嗪还可以拮抗吗啡引起的僵直和镇痛，但不能拮抗吗啡引起的热疗。纳曲酮没有改变吗啡引起的僵直。这些结果表明，μ1阿片样物质受体在吗啡奖励中起积极作用，而吗啡诱导的体温过高似乎不是由μ1阿片样物质受体介导的。此外，δ阿片受体似乎在吗啡诱导的奖赏中没有意义。

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