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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Perinatal exposure to morphine disrupts brain norepinephrine, ovarian cyclicity, and sexual receptivity in rats.
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Perinatal exposure to morphine disrupts brain norepinephrine, ovarian cyclicity, and sexual receptivity in rats.

机译：围产期吗啡暴露会破坏大鼠的大脑去甲肾上腺素，卵巢循环和性接受能力。

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The effect of perinatal exposure to morphine on the development of catecholaminergic and reproductive function in female rats was investigated. Adult rats received morphine intraperitoneally daily for 40 days. The dose of morphine was progressively increased at 10-day intervals from 5, 7.5, 10 to 15 mg/kg body weight until day 40. The rats were mated between days 38 and 45. Administration of morphine at dose rates of 20 and 30 mg/kg continued during pregnancy. The dose was increased to 40 mg/kg for 10 days postpartum. Results showed that morphine disrupted ovarian cyclicity in 52% of the females. Amongst the remaining females, 43% became pregnant when mated. In the female offspring born to such dams, sexual maturation was delayed and body weight was reduced until weaning. At adulthood, lordosis behavior was inhibited when the female offspring were tested against stimulus males. Plasma estradiol and ovarian estradiol and progesterone levels were reduced. Norepinephrine concentration in the hypothalamus was reduced, whereas it remained unchanged in the amygdala. Dopamine concentrations in both hypothalamus and amygdala were not influenced by perinatal morphine exposure. These results suggest that chronic morphine treatment during perinatal life selectively influences the development of noradrenergic mechanisms in the rat brain and this may in turn be responsible for reduced reproductive activity.
机译：研究了围产期吗啡暴露对雌性大鼠儿茶酚胺能和生殖功能发育的影响。成年大鼠每天腹膜内接受吗啡40天。吗啡的剂量以10天为间隔从5、7.5、10 mg / kg体重逐渐增加至40天。大鼠在38至45天交配。以20和30 mg的剂量施用吗啡/ kg在怀孕期间持续。产后10天剂量增加到40mg / kg。结果表明，吗啡破坏了52％的女性的卵巢循环。在其余的女性中，有43％会在怀孕时怀孕。在这样的水坝出生的雌性后代中，性成熟被延迟，体重降低直至断奶。在成年期，对雌性后代进行雄性刺激试验时，脊柱前凸行为受到抑制。血浆雌二醇和卵巢雌二醇及孕酮水平降低。下丘脑中去甲肾上腺素的浓度降低，而杏仁核中的去甲肾上腺素浓度保持不变。下丘脑和杏仁核中的多巴胺浓度不受围产期吗啡暴露的影响。这些结果表明，围产期生命中的慢性吗啡治疗选择性影响大鼠脑中去甲肾上腺素能机制的发展，这可能反过来导致生殖活动减少。

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