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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Chronic ethanol ingestion-induced changes in open-field behavior and oxidative stress in the rat.
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Chronic ethanol ingestion-induced changes in open-field behavior and oxidative stress in the rat.

机译：慢性乙醇摄入引起的大鼠旷场行为和氧化应激变化。

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摘要

The effects of chronic ethanol intoxication on the open-field behavior, on antioxidant enzyme activities, and the degree of lipid peroxidation were investigated. Rats consuming a liquid diet containing 7% ethanol for 4, 7, 14, or 21 days exhibited a significantly decreased ambulation activity, accompanied by a reduced frequency and duration of explorative rearing in an open-field task 4, 7, and 14 days after chronic ethanol ingestion, whereas presumed adaptation to the neurologic effects of ethanol was observed on day 21. Changes in the activities of glutathione peroxidase (GSH-Px): glutathione reductase (GSH-R), and catalase, and in the content of reduced glutathione (GSH) in blood samples were determined by means of biochemical methods. The degree of lipid peroxidation was measured via thiobarbituric acid assays. Chronic ethanol ingestion elicited a significant increase in GSH-Px activity (by a maximum of approximately 32% on day 14), whereas opposite alterations in GSH-R and catalase activities wererecorded (49% of the control value on day 4 and 17% on day 21, respectively). Highly elevated contents of thiobarbituric acid reactive substances reflected extensive lipid peroxidation processes throughout the experiment. These changes indicate that ethanol toxicity induces profound changes in explorative behavior, mediated, at least partly, by changes in the free radical metabolism.
机译：研究了慢性乙醇中毒对旷场行为，抗氧化酶活性和脂质过氧化程度的影响。在4、7、14或21天中，食用含7％乙醇的流质饮食的大鼠的活动能力显着降低，并且在野外训练后第4、7和14天，探索性饲养的频率和持续时间减少慢性乙醇摄入，但在第21天观察到了对乙醇神经系统作用的适应。谷胱甘肽过氧化物酶（GSH-Px）：谷胱甘肽还原酶（GSH-R）和过氧化氢酶活性的变化，以及还原型谷胱甘肽的含量变化通过生化方法测定血样中的（GSH）。脂质过氧化程度通过硫代巴比妥酸测定法测量。长期摄入乙醇会引起GSH-Px活性显着增加（第14天最多增加约32％），而记录的GSH-R和过氧化氢酶活性则发生相反的变化（第4天为对照值的49％，第4天为对照值的17％）。第21天）。整个实验过程中，高浓度的硫代巴比妥酸反应性物质含量高，反映了广泛的脂质过氧化过程。这些变化表明乙醇毒性引起探索性行为的深刻变化，至少部分地由自由基代谢的变化介导。

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