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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Hyperactivity induced by prenatal nicotine exposure is associated with an increase in cortical nicotinic receptors.
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Hyperactivity induced by prenatal nicotine exposure is associated with an increase in cortical nicotinic receptors.

机译：产前尼古丁暴露引起的机能亢进与皮质烟碱受体的增加有关。

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Prenatal exposure to nicotine may lead to hyperactivity. To evaluate possible involvement of central nicotinic receptors in this condition, pregnant Sprague-Dawley rats were implanted with osmotic minipumps to receive nicotine (6 mg/kg/day) or saline throughout gestation. A total of 222 pups (118 males and 104 females) from 24 dams were measured for locomotor activity. Male and female hyperactive and nonhyperactive offspring from each treatment group were selected and analyzed for nicotinic receptor concentrations in various brain regions. Hyperactive male offspring that were prenatally exposed to nicotine exhibited a significant increase in the cortical receptor densities without a change in binding affinity. Hyperactive offspring of saline-treated dams did not show an increase in cortical nicotinic receptors. These results suggest that hyperactive male offspring of nicotine-exposed dams are also susceptible to neurochemical effects of intrauterine nicotine exposure.
机译：产前暴露于尼古丁可能导致活动过度。为了评估这种情况下中央烟碱样受体的可能参与，将怀孕的Sprague-Dawley大鼠植入渗透性微型泵，使其在整个妊娠过程中接受尼古丁（6 mg / kg /天）或生理盐水。测量了来自24个水坝的222头幼崽（118头雄性和104头雌性）的运动能力。选择每个治疗组的雄性和雌性活动过度和非活动过度的后代，并分析各个大脑区域的烟碱样受体浓度。产前暴露于尼古丁的多动雄性后代表现出皮质受体密度的显着增加，而结合亲和力却没有改变。盐水处理过的水坝过活跃的后代并未显示皮质烟碱受体增加。这些结果表明，暴露于尼古丁的水坝活跃的雄性后代也容易受到宫内尼古丁暴露的神经化学作用的影响。

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