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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Fear-potentiated startle, but not light-enhanced startle, is enhanced by anxiogenic drugs.
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Fear-potentiated startle, but not light-enhanced startle, is enhanced by anxiogenic drugs.

机译：焦虑增强的惊吓，而不是光增强的惊吓，被焦虑症药物增强。

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RATIONALE AND OBJECTIVES: The light-enhanced startle paradigm (LES) is suggested to model anxiety, because of the non-specific cue and the long-term effect. In contrast, the fear-potentiated startle (FPS) is suggested to model conditioned fear. However, the pharmacological profiles of these two paradigms are very similar. The present study investigated the effects of putative anxiogenic drugs on LES and FPS and aimed at determining the sensitivity of LES for anxiogenic drugs and to potentially showing a pharmacological differentiation between these two paradigms. METHODS: Male Wistar rats received each dose of the alpha(2)-adrenoceptor antagonist yohimbine (0.25-1.0mg/kg), the 5-HT(2C) receptor agonist m-chlorophenylpiperazine (mCPP, 0.5-2.0mg/kg) or the GABA(A) inverse receptor agonist pentylenetetrazole (PTZ, 3-30mg/kg) and were subsequently tested in either LES or FPS. RESULTS: None of the drugs enhanced LES, whereas mCPP increased percentage FPS and yohimbine increased absolute FPS values. Furthermore, yohimbine increased baseline startle amplitude in the LES, while mCPP suppressed baseline startle in both the LES and FPS and PTZ suppressed baseline startle in the FPS. CONCLUSIONS: In contrast to findings in the FPS paradigm, none of the drugs were able to exacerbate the LES response. Thus, a clear pharmacological differentiation was found between LES and FPS.
机译：理由和目的：由于非特异性提示和长期作用，建议使用轻度增强的惊吓范例来建立焦虑模型。相反，建议将恐惧增强的惊吓（FPS）建模为条件恐惧。但是，这两种范例的药理特性非常相似。本研究调查了推定的抗焦虑药对LES和FPS的影响，旨在确定LES对抗焦虑药的敏感性，并可能显示这两种范式之间的药理学区别。方法：雄性Wistar大鼠接受每剂量的α（2）-肾上腺素受体拮抗剂育亨宾（0.25-1.0mg / kg），5-HT（2C）受体激动剂间氯苯哌嗪（mCPP，0.5-2.0mg / kg）或GABA（A）反向受体激动剂戊四氮（PTZ，3-30mg / kg），随后在LES或FPS中进行测试。结果：所有药物均未增强LES，而mCPP增加了FPS百分比，育亨宾增加了绝对FPS值。此外，育亨宾增加了LES的基线惊吓幅度，而mCPP抑制了LES和FPS的基线惊吓，而PTZ抑制了FPS的基线惊吓。结论：与FPS范式的发现相反，没有一种药物能够加剧LES反应。因此，在LES和FPS之间发现了明显的药理学区别。

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