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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Hedonic and motivational roles of opioids in food reward: implications for overeating disorders.
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Hedonic and motivational roles of opioids in food reward: implications for overeating disorders.

机译：阿片类物质在食物奖励中的享乐性和动机性作用：对暴饮暴食疾病的影响。

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摘要

Food reward can be driven by separable mechanisms of hedonic impact (food 'liking') and incentive motivation (food 'wanting'). Brain mu-opioid systems contribute crucially to both forms of food reward. Yet, opioid signals for food 'liking' and 'wanting' diverge in anatomical substrates, in pathways connecting these sites, and in the firing profiles of single neurons. Divergent neural control of hedonic and motivational processes raises the possibility for joint or separable modulation of food intake in human disorders associated with excessive eating and obesity. Early findings confirm an important role for 'liking' and 'wanting' in human appetitive behaviors, and suggest the intriguing possibility that exaggerated signals for 'wanting,' and perhaps 'liking,' may contribute to forms of overeating.
机译：食物享乐可由享乐影响（食物“喜欢”）和激励动机（食物“想要”）的独立机制驱动。脑类阿片系统对两种形式的食物奖励都至关重要。然而，食物“喜欢”和“想要”的阿片样物质信号在解剖学底物，连接这些位点的途径以及单个神经元的放电曲线中却有所不同。对享乐和动机过程的不同神经控制增加了与过量进食和肥胖有关的人类疾病中食物摄入的联合或可分调节的可能性。早期发现证实了“喜欢”和“想要”在人类食欲行为中的重要作用，并暗示了“想要”或“喜欢”的夸大信号可能助长暴饮暴食的可能性。

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