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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Intra-accumbens baclofen, but not muscimol, mimics the effects of food withdrawal on feeding behaviour.
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Intra-accumbens baclofen, but not muscimol, mimics the effects of food withdrawal on feeding behaviour.

机译：体内的巴氯芬，而不是麝香酚，模仿了断食对喂养行为的影响。

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Intra-accumbens stimulation of GABA receptors results in a robust increase in food intake. However the differential consequences of stimulating GABA(A) and GABA(B) receptors in the nucleus accumbens have not been extensively explored with respect to feeding behaviour. Here we compare the effects of the GABA(B) receptor agonist baclofen and GABA(A) receptor agonist muscimol, infused into the nucleus accumbens shell, on food intake and related behavior patterns. Baclofen (110-440 rhomol) dose dependently enhanced intake and delayed the onset of satiety within the test period as did the effects of 4-8h food withdrawal. Muscimol (220-660 rhomol) enhanced intake but also disrupted the sequence of associated behaviours at every dose tested. We conclude that GABA(B) receptors in the nucleus accumbens shell may play a role in relation to feeding motivation whereas GABA(A) receptors may, as previously suggested, have a more restricted role in relation to the motor components of approach to food and ingestion.
机译：内刺激GABA受体导致食物摄入量的强劲增加。但是，关于喂养行为，尚未广泛探讨刺激伏伏核中GABA（A）和GABA（B）受体的不同结果。在这里，我们比较了注入伏隔核壳中的GABA（B）受体激动剂巴氯芬和GABA（A）受体激动剂麝香酚对食物摄入和相关行为模式的影响。巴氯芬（110-440 rhomol）剂量依赖性地增加摄入量，并在试验期内延迟饱腹感的发作，停药4-8h的影响也是如此。 Muscimol（220-660 rhomol）可以增加摄入量，但在每个测试剂量下也会破坏相关行为的顺序。我们得出的结论是伏伏核壳中的GABA（B）受体可能与进食动机有关，而如先前所建议，GABA（A）受体与进食和进食的运动成分有关的作用可能更受限制。摄取。

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