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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Maternal high fat feeding and gestational dietary restriction: effects on offspring body weight, food intake and hypothalamic gene expression over three generations in mice.
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Maternal high fat feeding and gestational dietary restriction: effects on offspring body weight, food intake and hypothalamic gene expression over three generations in mice.

机译：孕妇高脂喂养和妊娠饮食限制：对小鼠三代后代体重，食物摄入和下丘脑基因表达的影响。

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Excessive gestational weight gain and maternal obesity have both been associated with increased incidence of obesity and metabolic disorder in offspring in both humans and animal models. The objectives of this study were to determine (1) whether mild gestational food restriction during the third trimester (GFR) would alter food intake and growth parameters of offspring, (2) whether effects of GFR depended on diet (high fat [HF] vs chow), (3) whether effects of excessive gestational weight gain (WG) would become magnified across generations, and (4) whether diet and GFR would alter hypothalamic gene expression in adult offspring. Three generations of female C57BL/6 mice were fed chow or HF diet, mated at 11 weeks of age and assigned to ad libitum feeding or 25% GFR. Offspring were fed the same diet as their mothers. Results showed (1) maternal gestational WG was positively correlated with offspring WG. (2) HF offspring weighed less (p<0.01) at weaning (WWT) but gained more during the 8 weeks after weaning than chow-fed offspring (p<0.05), resulting in higher final body weights (BW) (p<0.01). (3) HF males from GFR mothers had higher WWT (p<0.05), but subsequent WG and final BW were less (p<0.05) compared to males from ad lib mothers. (4) In the HF group, GFR also resulted in decreased FI (p<0.05) and FE (p<0.07) in offspring, compared to offspring from ad lib mothers. (5) In generation 3, hypothalamic expression of tyrosine hydroxylase was lower in HF males from GFR mothers compared to HF males from ad lib mothers (p<0.05). In conclusion, gender and maternal GFR had independent effects on growth and FI, and hypothalamic gene expression was dependent on both gender and maternal GFR in HF offspring. Even mild food restriction of obese mothers during pregnancy may have beneficial effects in reducing the risk or degree of obesity in offspring.
机译：在人类和动物模型中，妊娠期体重增加过多和母体肥胖都与肥胖和后代代谢紊乱的发生率增加有关。这项研究的目的是确定（1）妊娠中期轻度限制食物摄入是否会改变后代的食物摄入和生长参数，（2）GFR的影响是否取决于饮食（高脂[HF]与（3）过多的妊娠体重增加（WG）的影响是否会在各个世代之间被放大，以及（4）饮食和GFR是否会改变成年后代的下丘脑基因表达。给三代雌性C57BL / 6小鼠喂食普通食物或HF饮食，在11周龄时使其交配并随意喂养或25％GFR。给后代提供与母亲相同的饮食。结果表明：（1）孕妇妊娠WG与后代WG呈正相关。 （2）断奶（WWT）时，HF后代的体重较小（p <0.01），但断奶后8周内的体重增加比普通喂养的后代（p <0.05），导致最终体重（BW）更高（p <0.01） ）。 （3）来自GFR母亲的HF男性具有较高的WWT（p <0.05），但随后的WG和最终BW低于（ad

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