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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Antinociceptive effect of certain dihydroxy flavones in mice.
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Antinociceptive effect of certain dihydroxy flavones in mice.

机译：某些二羟基黄酮对小鼠的镇痛作用。

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OBJECTIVE: This study was designed to evaluate the antinociceptive action of four dihydroxy flavone derivatives; 3,3'-dihydroxy flavone, 5,6-dihydroxy flavone, 3,7-dihydroxy flavone and 6,3'-dihydroxy flavone and to investigate the mechanisms involved. MATERIALS AND METHODS: The antinociceptive effect of dihydroxy flavones was investigated in mice employing acetic acid induced abdominal constrictions, formalin-induced nociception, and hot plate assay procedures. The effects following pretreatment with naloxone, yohimbine, ondansetron, haloperidol, bicuculline and glibenclamide were also studied by acetic acid assay to reveal the involvement of opioid, adrenergic, tryptaminergic, dopaminergic, GABAergic or potassium channels respectively in the antinociceptive action of these compounds. RESULTS: Dihydroxy flavone derivatives significantly reduced the number of abdominal constrictions in acetic acid assay. The paw licking response time during both the early and late phases of formalin-induced nociception was reduced in a dose dependent manner by dihydroxy flavones treatment. A significant increase in reaction time was also evident in hot plate assay after dihydroxy flavones treatment. The antinociceptive effect of dihydroxy flavones in the acetic acid assay was significantly attenuated by pretreatment with either naloxone or bicuculline. However, pretreatment of animals with yohimbine, ondansetron, haloperidol, or glibenclamide did not alter the response. CONCLUSION: All the four investigated dihydroxy flavones produced dose related antinociception through mechanisms that involve an interaction with opioid and GABAergic pathways.
机译：目的：本研究旨在评估四种二羟基黄酮衍生物的镇痛作用。 3,3'-二羟基黄酮，5,6-二羟基黄酮，3,7-二羟基黄酮和6,3'-二羟基黄酮并研究其机理。材料与方法：用乙酸诱导的腹部收缩，福尔马林诱导的伤害感受和热板试验程序研究了小鼠体内二羟基黄酮的镇痛作用。还通过乙酸测定法研究了用纳洛酮，育亨宾，恩丹西酮，氟哌啶醇，双瓜氨酸和格列本脲预处理后的作用，以揭示阿片样物质，肾上腺素能，类胰药能，多巴胺能，GABA能或钾通道分别参与了这些化合物的抗伤害感受作用。结果：二羟基黄酮衍生物显着减少了乙酸测定中腹部收缩的数量。通过二羟基黄酮治疗，福尔马林诱导的伤害感受的早期和晚期的舔足反应时间均以剂量依赖性方式减少。在二羟基黄酮处理后的热板测定中，反应时间也明显增加。通过用纳洛酮或双瓜氨酸预处理，醋酸检测中的二羟基黄酮的抗伤害感受作用显着减弱。但是，用育亨宾，恩丹西酮，氟哌啶醇或格列本脲对动物进行预处理不会改变反应。结论：所有四个被研究的二羟基黄酮通过与阿片样物质和GABA能途径相互作用的机制产生了剂量相关的抗伤害感受。

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