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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Antinociceptive activity of Annona diversifolia Saff. leaf extracts and palmitone as a bioactive compound.
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Antinociceptive activity of Annona diversifolia Saff. leaf extracts and palmitone as a bioactive compound.

机译：番荔枝番荔枝的抗伤害感受活性。叶提取物和棕榈酮为生物活性化合物。

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Annonas are consumed as fresh fruits, but are also widely used in folk medicine for treating pain and other ailments. Antinociceptive properties of the Annona diversifolia ethanol crude extract were tested using the pain-induced functional impairment model in rat (PIFIR) and the writhing test in mice. The ethanol extract caused a 25% recovery of limb function in rats; this response was significant and dose-dependent. Furthermore, this extract produced a similar antinociceptive response (ED(50)=15.35 mg/kg) to that of the reference drug tramadol (ED(50)=12.42 mg/kg) when evaluated in the writhing test in mice. Bio-guided fractionation yielded hexane and acetone active fractions from which the presence of palmitone and flavonoids was respectively detected. Palmitone produced an antinociceptive response with an ED(50)=19.57 mg/kg in the writhing test. Antinociceptive responses from ethanol extract and tramadol were inhibited in the presence of either naloxone (1mg/kg, s.c.)--an antagonist of endogenous opioids--or WAY100635 (0.8 mg/kg, s.c.)--a 5-HT(1A) serotonin receptor antagonist. These results provide evidence that A. diversifolia possesses antinociceptive activity, giving support to their traditional use for treatment of spasmodic and arthritic pain. In addition, our results suggest the participation of endogenous opioids and 5-HT(1A) receptors in this antinociceptive response.
机译：番荔枝作为新鲜水果被消费，但也广泛用于治疗疼痛和其他疾病的民间医学中。使用大鼠中的疼痛诱导的功能障碍模型（PIFIR）和小鼠的扭体试验测试了Annona diversifolia乙醇粗提物的镇痛特性。乙醇提取物可导致大鼠肢体功能恢复25％。这种反应是显着的并且是剂量依赖性的。此外，当在小鼠的扭体试验中进行评估时，该提取物产生了与参考药物曲马多相似的镇痛反应（ED（50）= 15.35 mg / kg）（ED（50）= 12.42 mg / kg）。生物引导分馏产生己烷和丙酮活性馏分，分别从其中检测到棕榈酮和类黄酮的存在。在扭体试验中，棕榈酮产生抗伤害感受的反应，ED（50）= 19.57 mg / kg。在纳洛酮（1mg / kg，sc）-内源阿片类药物的拮抗剂-或WAY100635（0.8 mg / kg，sc）-5-HT（1A）的存在下，乙醇提取物和曲马多的抗伤害感受反应受到抑制。血清素受体拮抗剂。这些结果提供了证明，A。diversifolia具有抗伤害感受活性，支持其传统疗法用于治疗痉挛性和关节炎性疼痛。此外，我们的结果表明内源性阿片类药物和5-HT（1A）受体参与了这种抗伤害感受性反应。

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