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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Lack of long-term behavioral alterations after early postnatal treatment with tropisetron: Implications for developmental psychobiology.
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Lack of long-term behavioral alterations after early postnatal treatment with tropisetron: Implications for developmental psychobiology.

机译：托吡司琼在产后早期治疗后缺乏长期行为改变：对发展心理生物学的影响。

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The early postnatal period represents a critical time window for brain development. Transient Cajal-Retzius cells in layer I of the cortex play an important role in cortical lamination by modulating neuronal migration and maturation. Recent data have demonstrated that the 5-HT(3) receptor antagonist and alpha7 nicotinic receptor partial agonist tropisetron, acting via 5-HT(3) receptors expressed on Cajal-Retzius cells, can disturb the formation of cortical columns at perinatal stages. This process is thought to be involved in several neuropsychiatric disorders. Here we investigated the possible long-term behavioral effects of exposure to tropisetron at early postnatal stages in mice. We found that the administration of 1mg/kg, intraperitoneal (i.p.) tropisetron from postnatal days 2-12 (P2-P12) did not induce significant cognitive, schizophrenia-like or emotional alterations in tropisetron-treated animals as compared to controls, when tested in multiple behavioral assays. These results may be of relevance regarding the possible protracted deleterious neuropsychiatric effects of tropisetron during early life.
机译：产后早期代表了大脑发育的关键时间窗口。皮质第一层中的瞬时Cajal-Retzius细胞通过调节神经元迁移和成熟在皮质层积中起重要作用。最新数据表明，通过Cajal-Retzius细胞上表达的5-HT（3）受体起作用的5-HT（3）受体拮抗剂和α7烟碱样受体部分激动剂tropisetron可能会扰乱围产期皮质柱的形成。该过程被认为与几种神经精神疾病有关。在这里，我们研究了在小鼠出生后早期暴露于托吡司琼可能产生的长期行为影响。我们发现，与对照组相比，出生后2-12天（P2-P12）服用1mg / kg腹膜内（ip）托吡司琼与对照组相比，并没有产生明显的认知，精神分裂症样或情绪改变。在多种行为分析中。这些结果可能与托吡司琼在生命早期可能产生的长期有害神经精神作用有关。

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