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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice.
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Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice.

机译：由5-甲氧基-N，N-二甲基色胺在野生型和CYP2D6人源化小鼠中进行刺激控制。

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In previous studies we have observed that, in comparison with wild type mice, Tg-CYP2D6 mice have increased serum levels of bufotenine [5-hydroxy-N,N-dimethyltryptamine] following the administration of 5-MeO-DMT. Furthermore, following the injection of 5-MeO-DMT, harmaline was observed to increase serum levels of bufotenine and 5-MeO-DMT in both wild-type and Tg-CYP2D6 mice. In the present investigation, 5-MeO-DMT-induced stimulus control was established in wild-type and Tg-CYP2D6 mice. The two groups did not differ in their rate of acquisition of stimulus control. When tested with bufotenine, no 5-MeO-DMT-appropriate responding was observed. In contrast, the more lipid soluble analog of bufotenine, acetylbufotenine, was followed by an intermediate level of responding. The combination of harmaline with 5-MeO-DMT yielded a statistically significant increase in 5-MeO-DMT-appropriate responding in Tg-CYP2D6 mice; a comparable increase occurred in wild-type mice. In addition, it was noted that harmaline alone was followed by a significant degree of 5-MeO-DMT-appropriate responding in Tg-CYP2D6 mice. It is concluded that wild-type and Tg-CYPD2D6 mice do not differ in terms of acquisition of stimulus control by 5-MeO-DMT or in their response to bufotenine and acetylbufotenine. In both groups of mice, harmaline was found to enhance the stimulus effects of 5-MeO-DMT.
机译：在先前的研究中，我们观察到，与野生型小鼠相比，Tg-CYP2D6小鼠在服用5-MeO-DMT后具有增加的血清丁丁烯碱[5-羟基-N，N-二甲基色胺]水平。此外，在注射5-MeO-DMT后，在野生型和Tg-CYP2D6小鼠中均观察到了harmaline可以提高丁苯丁胺和5-MeO-DMT的血清水平。在本研究中，在野生型和Tg-CYP2D6小鼠中建立了5-MeO-DMT诱导的刺激控制。两组在获得刺激控制上没有差异。用布丁宁进行测试时，未观察到5-MeO-DMT适当的应答。相比之下，丁苯丁宁的脂溶性更高的类似物乙酰丁苯丁宁，其后是中等水平的应答。 harmaline与5-MeO-DMT的组合在Tg-CYP2D6小鼠中产生了5-MeO-DMT适当响应的统计学显着增加;在野生型小鼠中发生了可比的增加。此外，注意到在Tg-CYP2D6小鼠中，单独使用harmaline会产生显着程度的5-MeO-DMT适当响应。结论是，野生型和Tg-CYPD2D6小鼠在通过5-MeO-DMT获得刺激控制或它们对丁丁橡胶和乙酰丁丁橡胶的反应方面没有差异。在两组小鼠中，均发现harmaline可增强5-MeO-DMT的刺激作用。

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