• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of anxiolytics in zebrafish: similarities and differences between benzodiazepines, buspirone and ethanol.
【24h】

Effects of anxiolytics in zebrafish: similarities and differences between benzodiazepines, buspirone and ethanol.

机译：斑马鱼抗焦虑药的影响：苯二氮卓类，丁螺环酮和乙醇之间的异同。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There is growing interest in zebrafish as a model organism in behavioral pharmacology research. Several anxiety behaviors have been characterized in zebrafish, but the effect of anxiolytic drugs on these parameters has been scarcely studied. The purpose of this work was to assess the predictive validity of acute treatment with anxiolytic drugs on behavioral parameters of anxiety. In the first task we simultaneously observed behavior of adult zebrafish on four parameters: height in the tank, locomotion, color, and shoal cohesion. The second task was the assessment of light/dark preference for 5 min. The benzodiazepines clonazepam, bromazepam, diazepam, and a moderate dose of ethanol significantly reduced shoal cohesion. Buspirone specifically increased zebrafish exploration of higher portions of the tank. In the light/dark task, all benzodiazepines, buspirone, and ethanol increased time spent in the light compartment. After treatment with anxiolytics, fish typically spent more than 60s and rarely less than 40s in the light compartment whereas controls (n=45) spent 33.3+/-14.4s and always less than 60s in the light compartment. Propranolol had no clear effects in these tasks. These results suggest that light/dark preference in zebrafish is a practical, low-cost, and sensitive screening task for anxiolytic drugs. Height in the tank and shoal cohesion seem to be useful behavioral parameters in discriminating different classes of these drugs.
机译：在行为药理学研究中，斑马鱼作为模型生物越来越受到关注。斑马鱼已表征了几种焦虑行为，但很少研究抗焦虑药对这些参数的影响。这项工作的目的是评估抗焦虑药物对焦虑行为参数的预测有效性。在第一个任务中，我们同时在四个参数上观察了成年斑马鱼的行为：坦克高度，运动，颜色和浅滩凝聚力。第二项任务是评估明暗偏好5分钟。苯二氮卓类药物氯硝西am，溴马西m，地西epa和适量的乙醇会明显降低浅滩的内聚力。丁螺环酮专门增加了斑马鱼对水箱较高部分的探索。在明/暗任务中，所有苯并二氮杂,、丁螺环酮和乙醇会增加在明室中花费的时间。用抗焦虑药治疗后，鱼通常在灯室中花费超过60s，很少少于40s，而对照组（n = 45）在灯室中花费33.3 +/- 14.4s，并且总是少于60s。普萘洛尔在这些任务中没有明显的作用。这些结果表明，斑马鱼的明/暗偏好是一种抗焦虑药物的实用，低成本和敏感的筛选任务。坦克的高度和浅滩的内聚力似乎是区分这些药物不同类别的有用的行为参数。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号