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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >D-amphetamine stimulates unconditioned exploration/approach behaviors in crayfish: Towards a conserved evolutionary function of ancestral drug reward.
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D-amphetamine stimulates unconditioned exploration/approach behaviors in crayfish: Towards a conserved evolutionary function of ancestral drug reward.

机译：D-苯丙胺刺激小龙虾的无条件探索/接近行为：朝着祖先药物奖励的保守进化功能发展。

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摘要

In mammals, rewarding properties of drugs depend on their capacity to activate a dopamine-mediated appetitive motivational seeking state--a system that allows animals to pursue and find all kinds of objects and events needed for survival. With such states strongly conserved in evolution, invertebrates have recently been developed into a powerful model in addiction research, where a shared ancestral brain system for the acquisition of reward can mediate drug addiction in many species. A conditioned place preference paradigm has illustrated that crayfish seek out environments that had previously been paired with psychostimulant and opioid administration. The present work demonstrates that the administration of D-amphetamine stimulates active explorative behaviors in crayfish through the action of the drug within their head ganglion. Crayfish, with a modularly organized and experimentally accessible, ganglionic nervous system offers a unique model to investigate (1) the fundamental, biological mechanisms of addictive drug reward; (2) how an appetitive/seeking disposition is implemented in a simple neural system, and (3) how it mediates the rewarding actions of major drugs of abuse.
机译：在哺乳动物中，药物的奖励性质取决于其激活多巴胺介导的食欲性动机寻求状态的能力，该系统使动物能够追求并找到生存所需的各种物体和事件。由于这些状态在进化中被严格保守，因此无脊椎动物最近已发展成成瘾研究的强大模型，在该模型中，用于获得奖励的共享祖先脑系统可以介导许多物种的成瘾性。有条件的地方偏爱范例说明，小龙虾会寻找先前与精神刺激药和阿片类药物配合使用的环境。目前的工作表明，D-苯异丙胺的给药通过小龙虾头部神经节中药物的作用刺激小龙虾的主动探索行为。小龙虾具有模块化组织和实验可访问的神经节神经系统，提供了一种独特的模型来研究（1）成瘾药物奖励的基本生物学机制; （2）如何在简单的神经系统中实现食欲/寻求的态度，以及（3）如何介导主要滥用药物的奖励行为。

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