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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats.
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Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats.

机译：在大鼠中接受5-氟尿嘧啶和环磷酰胺治疗后，保留了学习记忆。

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Some patients experience enduring cognitive impairment after cancer treatment, a condition termed "chemofog". Animal models allow assessment of chemotherapy effects on learning and memory per se, independent of changes due to cancer itself or associated health consequences such as depression. The present study examined the long-term learning and memory effects of a chemotherapy cocktail used widely in the treatment of breast cancer, consisting of 5-fluorouracil (5FU) and cyclophosphamide (CYP). Eighty 5-month old male F344 rats received contextual and cued fear conditioning before treatment with saline, or a low or high dose drug cocktail (50mg/kg CYP and 75 mg/kg 5FU, or 75 mg/kg CYP and 120 mg/kg 5FU, i.p., respectively) every 30 days for 2 months. After a 2-month, no-drug recovery, both long-term retention and new task acquisition in the water maze and 14-unit T-maze were assessed. Neither dose of the CYP/5FU cocktail impaired retrograde fear memory despite marked toxicity documented by enduring weight loss and 50% mortality at the higher dose. Acquisition in the water maze and Stone maze was also normal relative to controls in rats treated with CYP/5FU. The results contribute to a growing literature suggesting that learning and memory mediated by the hippocampus can be relatively resistant to chemotherapy. Future investigation may need to focus on assessments of processing speed, executive function and attention, and the possible interactive contribution of cancer itself and aging to the post-treatment development of cognitive impairment.
机译：一些患者在癌症治疗后经历了持久的认知障碍，这种疾病被称为“ chemofog”。动物模型可以评估化疗对学习和记忆的影响，而不受癌症本身或相关健康后果（例如抑郁症）引起的变化的影响。本研究检查了广泛用于治疗乳腺癌的化学疗法鸡尾酒的长期学习和记忆效应，该疗法由5-氟尿嘧啶（5FU）和环磷酰胺（CYP）组成。八十只5个月大的雄性F344大鼠在接受生理盐水或低剂量或高剂量药物鸡尾酒（50mg / kg CYP和75mg / kg 5FU或75mg / kg CYP和120mg / kg每30天一次，分别为5FU，ip），持续2个月。经过2个月的无药物恢复后，评估了水迷宫和14单位T型迷宫的长期保留和新任务获得。 CYP / 5FU鸡尾酒的两种剂量均未损害逆行恐惧记忆，尽管经长期服用可减轻体重并具有50％的死亡率，但仍显示出明显的毒性。相对于用CYP / 5FU治疗的大鼠的对照组，在水迷宫和石迷宫中的采集也正常。该结果有助于越来越多的文献表明，海马介导的学习和记忆对化学疗法具有相对的抵抗力。未来的研究可能需要集中于对处理速度，执行功能和注意力的评估，以及癌症本身和衰老对认知障碍治疗后发展的可能相互作用。

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