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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >ADHD medication reduces cotinine levels and withdrawal in smokers with ADHD.
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ADHD medication reduces cotinine levels and withdrawal in smokers with ADHD.

机译：ADHD药物可降低吸烟者患有ADHD的可替宁水平和戒断。

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Individuals with ADHD may self-medicate with nicotine, the main psychoactive ingredient in tobacco smoke, in order to reduce symptoms and negative moods associated with ADHD. ADHD medication (e.g., methylphenidate and atomoxetine) may mimic some of the effects of nicotine and may aid smoking cessation in smokers with ADHD. The present study examined if ADHD medication reduces smoking and withdrawal in non-treatment seeking smokers with ADHD. Fifteen adult smokers with ADHD participated in the study, which consisted of an experimental phase and field monitoring phase to examine the acute and extended effects, respectively, of ADHD medication. During the experimental phase, smokers were asked to complete a Continuous Performance Task (CPT) and the Shiffman-Jarvik smoking withdrawal questionnaire during the following four conditions: (1) ADHD medication+cigarette smoking, (2) ADHD medication+overnight abstinence, (3) placebo+cigarette smoking, and (4) placebo+overnight abstinence. During the field monitoring phase, participants were asked to provide salivary cotinine samples and complete electronic diaries about smoking, smoking urge, ADHD symptoms, and stress in everyday life for two days on ADHD medication and for two days on placebo. Results of the experimental phase showed that ADHD medication improved task performance on the CPT and reduced withdrawal during overnight abstinence. During the field monitoring phase, ADHD medication reduced salivary cotinine levels compared to placebo. In addition, the electronic diary revealed that ADHD medication improved difficulty concentrating during no smoking events and stress. The findings of the present study suggest that, along with other strategies, ADHD medication may be used to aid smoking withdrawal and cessation in smokers with ADHD.
机译：患有多动症的人可以自行服用烟草烟雾中的主要精神活性成分尼古丁，以减轻与多动症有关的症状和负面情绪。 ADHD药物（例如，哌醋甲酯和托莫西汀）可能模仿尼古丁的某些作用，并可能帮助患有ADHD的吸烟者戒烟。本研究检查了多动症药物是否可减少非治疗性多动症吸烟者的吸烟和戒断。 15名患有ADHD的成年吸烟者参加了该研究，该研究包括一个实验阶段和现场监测阶段，分别检查ADHD药物的急性和扩展作用。在实验阶段，要求吸烟者在以下四个条件下完成一项持续表现任务（CPT）和Shiffman-Jarvik戒烟问卷：（1）ADHD药物+香烟吸烟;（2）ADHD药物+过夜戒酒，（ 3）安慰剂+吸烟，以及（4）安慰剂+过夜戒酒。在现场监测阶段，要求参与者提供唾液可替宁样品和有关吸烟，吸烟倾向，ADHD症状和日常生活中压力的完整电子日记，使用ADHD药物治疗两天，使用安慰剂药物治疗两天。实验阶段的结果表明，ADHD药物改善了CPT的任务表现，并减少了整夜禁欲期间的戒断。在现场监测阶段，与安慰剂相比，ADHD药物可降低唾液可替宁水平。此外，电子日记显示，多动症药物可改善无烟事件和压力时集中注意力的困难。本研究的发现表明，与其他策略一起，ADHD药物可用于帮助患有ADHD的吸烟者戒烟和戒烟。

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