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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Alcohol-preferring (P) rats are more sensitive than Wistar rats to the reinforcing effects of cocaine self-administered directly into the nucleus accumbens shell.
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Alcohol-preferring (P) rats are more sensitive than Wistar rats to the reinforcing effects of cocaine self-administered directly into the nucleus accumbens shell.

机译：嗜酒精（P）大鼠比Wistar大鼠对可卡因直接自行给药到伏隔核壳中的增强作用更敏感。

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Wistar rats will self-administer cocaine directly into the nucleus accumbens shell (AcbSh), but not into the nucleus accumbens core. In human and animal literature, there is a genetic association between alcoholism and cocaine dependency. The current experiment examined whether selective breeding for high alcohol preference is also associated with greater sensitivity of the AcbSh to the reinforcing properties of cocaine. P and Wistar rats were given cocaine (0, 100, 200, 400, or 800 pmol/100 nl) to self-infuse into the AcbSh. Rats were given cocaine for the first 4 sessions (acquisition), artificial CSF for sessions 5 and 6 (extinction), and cocaine again in session 7 (reinstatement). During acquisition, P rats self-infused 200-800 pmol cocaine (59 infusions/session), whereas Wistar rats only reliably self-infused 800 pmol cocaine (38 infusions/session). Furthermore, P rats received a greater number of cocaine infusions in the 200, 400 and 800 pmol cocaine groups compared to respective Wistar groups during acquisition. Both P and Wistar rats reduced responding on the active lever when aCSF was substituted for cocaine, and reinstated responding in session 7 when cocaine was restored. However, P rats had significantly greater infusions during session 7 compared to session 4 at all concentrations of cocaine tested, whereas Wistar rats only displayed greater infusions during session 7 compared to session 4 at the 400 and 800 pmol cocaine concentrations. The present results suggest that, compared to Wistar rats, the AcbSh of P rats was more sensitive to the reinforcing effects of cocaine. The reinstatement data suggest that the AcbSh of P rats may have become sensitized to the reinforcing effects of cocaine. Overall, the findings from this study support a genetic association between high alcohol preference and greater sensitivity to the reinforcing effects of cocaine.
机译：Wistar大鼠将可卡因直接自我给药到伏隔核壳（AcbSh）中，但不直接向伏隔核核心内给药。在人类和动物文学中，酗酒与可卡因依赖之间存在遗传联系。当前的实验研究了高酒精偏好的选择性育种是否还与AcbSh对可卡因增强特性的更高敏感性相关。给P和Wistar大鼠可卡因（0、100、200、400或800 pmol / 100 nl）自我注入AcbSh。在开始的第四个阶段（采集）中给大鼠服用可卡因，在第5和第6阶段（消灭）中给予人造CSF，在第7阶段（恢复）中再次给予可卡因。在采集过程中，P大鼠自我输注200-800 pmol可卡因（每次输注59次），而Wistar大鼠仅可靠地自我输注800 pmol可卡因（每次输注38次）。此外，与采集过程中的各个Wistar组相比，P大鼠在200、400和800 pmol可卡因组中接受了更多的可卡因输注。当用aCSF代替可卡因时，P和Wistar大鼠均降低了对活动杠杆的反应，而在恢复第7阶段后，在第7节中恢复了反应。但是，在所有可卡因浓度下，P组大鼠在第7阶段的输注量均高于第4阶段，而Wistar大鼠在第7阶段仅显示400和800 pmol可卡因浓度下的输注量。目前的结果表明，与Wistar大鼠相比，P大鼠的AcbSh对可卡因的增强作用更为敏感。恢复数据表明，P大鼠的AcbSh可能已对可卡因的增强作用敏感。总的来说，这项研究的结果支持了高酒精偏好与对可卡因增强作用的更高敏感性之间的遗传联系。

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