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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Memory facilitating effects of agomelatine in the novel object recognition memory paradigm in the rat.
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Memory facilitating effects of agomelatine in the novel object recognition memory paradigm in the rat.

机译：阿戈美拉汀在大鼠新型物体识别记忆范例中的记忆促进作用。

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摘要

The aim of the present study was to evaluate the effects of agomelatine, an antidepressant with melatonergic agonist and 5-HT(2C) antagonist properties, in the rat novel object recognition (NOR) task, a model of short-term episodic memory. To assess the potential involvement of its chronobiotic activity, single intraperitoneal administration of agomelatine and NOR testing were performed either in the evening or in the morning. In both conditions, using a 24h retention interval, vehicle-treated rats did not discriminate between the novel and the familiar object (recognition index was not different from chance performance) while object memory performance of rats treated with agomelatine either in the evening (10 and 40mg/kg) or in the morning (2.5, 10, and 40mg/kg) was significantly improved. Moreover, the selective 5-HT(2C) antagonist SB 242,084 (0.63, 2.5, and 10mg/kg) and melatonin (2.5, 10, and 40mg/kg) displayed also memory facilitating effects in both administration conditions. Finally, thioperamide used as positive reference compound to validate the experimental conditions, demonstrated a memory facilitating effect. In conclusion, agomelatine was shown to possess memory facilitating effects in the rat NOR task and both melatonergic agonist and 5-HT(2C) antagonist properties could be involved in these effects.
机译：本研究的目的是评估阿戈美拉汀，一种具有褪黑素能激动剂和5-HT（2C）拮抗剂特性的抗抑郁药，在大鼠新对象识别（NOR）任务（一种短期情景记忆模型）中的作用。为了评估其生时活性的潜在影响，在傍晚或早晨进行腹腔注射阿戈美拉汀和NOR试验。在这两种情况下，使用24h的保留间隔，媒介物处理的大鼠在新奇事物与熟悉的物体之间没有区别（识别指数与偶然表现没有区别），而在晚上用阿戈美拉汀治疗的大鼠的物体记忆表现（10和10）。 40mg / kg）或早晨（2.5、10和40mg / kg）明显改善。此外，选择性5-HT（2C）拮抗剂SB 242,084（0.63、2.5和10mg / kg）和褪黑激素（2.5、10和40mg / kg）在两种给药条件下均显示出记忆促进作用。最后，硫代过酰胺用作阳性参考化合物以验证实验条件，显示出促进记忆的作用。总之，显示阿戈美拉汀在大鼠NOR任务中具有促进记忆的作用，而褪黑素激动剂和5-HT（2C）拮抗剂的性质均可能与这些作用有关。

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