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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Piracetam, an AMPAkine drug, facilitates memory consolidation in the day-old chick
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Piracetam, an AMPAkine drug, facilitates memory consolidation in the day-old chick

机译：吡拉西坦，一种AMPAkine药物，可促进日龄雏鸡的记忆巩固

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Piracetam is an AMPAkine drug that may have a range of different mechanisms at the cellular level, and which has been shown to facilitate memory, amongst its other effects. This series of experiments demonstrated that a 10 mg/kg dose of piracetam facilitated memory consolidation in the day-old chick when injected from immediately until 120 min after weak training (i.e. using a 20% v/v concentration of methyl anthranilate) with the passive avoidance learning task. Administration of piracetam immediately after training led to memory facilitation which lasted for up to 24 h following training. This dose of the AMPAkine was not shown to facilitate memory reconsolidation. These findings support the contention that application of the AMPAkine piracetam facilitates memory using a weak training task, and extend the range of actions previously noted with NMDA-related agents to those which also facilitate the AMPA receptor.
机译：吡拉西坦是一种AMPAkine药物，在细胞水平上可能具有多种不同的作用机制，除其他作用外，已被证明可促进记忆。该系列实验表明，当从被动训练（即使用20％v / v浓度的邻氨基苯甲酸甲酯）进行弱训练（即使用20％v / v浓度的邻氨基苯甲酸甲酯）后立即注射至120分钟时，剂量为10 mg / kg的吡乙酰胺促进了成年小鸡的记忆巩固回避学习任务。训练后立即服用吡乙酰胺可导致记忆促进，训练后持续长达24小时。未显示该剂量的AMPAkine有助于记忆重建。这些发现支持这样的论点，即使用弱势训练任务应用AMPAkine吡乙酰胺会促进记忆，并将先前使用NMDA相关药物指出的作用范围扩大到也能促进AMPA受体的作用范围。

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