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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: Evidence for the involvement of the dopaminergic system
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Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: Evidence for the involvement of the dopaminergic system

机译：从迷迭香中提取的熊果酸对小鼠的抗抑郁样作用：多巴胺能系统参与的证据

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摘要

Ursolic acid, a constituent from Rosmarinus officinalis, is a triterpenoid compound which has been extensively known for its anticancer and antioxidant properties. In the present study, we investigated the antidepressant-like effect of ursolic acid isolated from this plant in two predictive tests of antidepressant property, the tail suspension test (TST) and the forced swimming test (FST) in mice. Furthermore, the involvement of dopaminergic system in its antidepressant-like effect was investigated in the TST. Ursolic acid reduced the immobility time in the TST (0.01 and 0.1 mg/kg, p.o.) and in the FST (10 mg/kg, p.o.), similar to fluoxetine (10 mg/kg, p.o.), imipramine (1 mg/kg, p.o.) and bupropion (10 mg/kg, p.o.). The effect of ursolic acid (0.1 mg/kg, p.o.) in the TST was prevented by the pretreatment of mice with SCH23390 (0.05 mg/kg, s.c., a dopamine D 1 receptor antagonist) and sulpiride (50 mg/kg, i.p., a dopamine D 2 receptor antagonist). The administration of a sub-effective dose of ursolic acid (0.001 mg/kg, p.o.) in combination with sub-effective doses of SKF38393 (0.1 mg/kg, s.c., a dopamine D 1 receptor agonist), apomorphine (0.5 μg/kg, i.p., a preferential dopamine D 2 receptor agonist) or bupropion (1 mg/kg, i.p., a dual dopamineoradrenaline reuptake inhibitor) reduced the immobility time in the TST as compared with either drug alone. Ursolic acid and dopaminergic agents alone or in combination did not cause significant alterations in the locomotor and exploratory activities. These results indicate that the antidepressant-like effect of ursolic acid in the TST is likely mediated by an interaction with the dopaminergic system, through the activation of dopamine D 1 and D 2 receptors.
机译：熊果酸（Rosmarinus officinalis的成分）是一种三萜类化合物，因其抗癌和抗氧化特性而广为人知。在本研究中，我们在两种抗抑郁特性的预测测试（尾部悬浮测试（TST）和强迫游泳测试（FST））中调查了从该植物中分离得到的熊果酸的抗抑郁样作用。此外，在TST中研究了多巴胺能系统参与其抗抑郁样作用。乌索酸减少了TST（0.01和0.1 mg / kg，po）和FST（10 mg / kg，po）的固定时间，类似于氟西汀（10 mg / kg，po），丙咪嗪（1 mg / kg） ，po）和安非他酮（10 mg / kg，po）。用SCH23390（0.05 mg / kg，sc，多巴胺D 1受体拮抗剂）和舒必利（50 mg / kg，腹膜内注射）预处理小鼠，可预防熊果酸（0.1 mg / kg，口服）在TST中的作用。多巴胺D 2受体拮抗剂）。亚有效剂量的熊果酸（0.001 mg / kg，口服）与亚有效剂量的SKF38393（0.1 mg / kg，sc，多巴胺D 1受体激动剂），阿扑吗啡（0.5μg/ kg）联合给药，ip，一种优先的多巴胺D 2受体激动剂）或安非他酮（1 mg / kg，ip，一种多巴胺/去甲肾上腺素再摄取抑制剂）与单独使用任一药物相比，减少了TST的固定时间。熊果酸和多巴胺能药物单独或联合使用不会引起运动和探索活动的重大改变。这些结果表明熊果酸在TST中的抗抑郁样作用可能是通过多巴胺D 1和D 2受体的活化与多巴胺能系统相互作用而介导的。

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