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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Early-life social experiences in mice affect emotional behaviour and hypothalamic-pituitary-adrenal axis function
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Early-life social experiences in mice affect emotional behaviour and hypothalamic-pituitary-adrenal axis function

机译：小鼠的早期社交经历会影响情绪行为和下丘脑-垂体-肾上腺轴功能

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Rationale: Early-life stressful experiences are associated to alterations in behavioural responses and development of psychiatric and neurodegenerative diseases. In rodents, individual housing is considered as a stressful condition whilst enriched environment can protect against stress and its negative consequences. Neuroendocrine responses to stress can also be altered by early-life experiences and seem to contribute to behavioural alterations induced by changes in housing conditions. Objective: To develop an improved procedure of social isolation throughout development (from pre-adolescence to adulthood) in CD1 mice and to elucidate its effects on behavioural parameters related to stress and neuroendocrine responses compared to enriched or social conditions. Materials and methods: CD1 male mice (PND 21) were housed in social/standard conditions, enriched conditions or isolated conditions during seven weeks. After that, different relevant behaviours were evaluated, including locomotor activity, anxiety-like and despair behaviour. Levels of plasma corticosterone were also analysed before and after a stressful event. Results: CD1 mice exposed to an isolated environment exhibited higher locomotion and anxiety-like responses than animals exposed to social or enriched conditions. In addition, isolated animals showed lower basal plasma corticosterone than social or enriched ones but after a stressful event the elevation of plasma corticosterone was higher, suggesting an enhanced response of the HPA axis to a novel and stressful situation. Conclusions: Social interaction is an important feature to display an appropriate behavioural and neuronal development. Habituation to novel stimuli is impaired in subjects exposed to social isolation and induces increased excitability response to stressful events. Social deprivation increases the possibility of altered neuronal function and could facilitate the development of neuropsychiatric disorders in adulthood.
机译：理由：早年的压力经历与行为反应的改变以及精神疾病和神经退行性疾病的发展有关。在啮齿动物中，单独的住房被认为是一种压力条件，而丰富的环境可以防止压力及其负面影响。神经内分泌对压力的反应也可以通过早期的生活经历来改变，并且似乎是由于居住条件的改变而引起的行为改变。目的：在CD1小鼠的整个发育过程中（从青春期到成年），开发一种改进的社会隔离程序，并阐明与丰富或社会条件相比，它对与压力和神经内分泌反应有关的行为参数的影响。材料和方法：将CD1雄性小鼠（PND 21）饲养在社交/标准条件，致富条件或孤立条件下，持续7周。之后，评估了不同的相关行为，包括运动活动，焦虑样和绝望行为。还分析了应激事件前后的血浆皮质酮水平。结果：暴露于孤立环境中的CD1小鼠比暴露于社交或丰富条件下的动物表现出更高的运动和焦虑样反应。此外，离群动物的基础血浆皮质酮水平低于社交动物或丰富动物，但在应激事件后血浆皮质酮水平升高，提示HPA轴对新型应激状态的反应增强。结论：社交互动是显示适当的行为和神经元发育的重要特征。处于社会孤立状态的对象会削弱对新刺激的习惯，并导致对压力事件的兴奋性反应增强。社会剥夺增加了神经元功能改变的可能性，并可能促进成年期神经精神疾病的发展。

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