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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Microinjection of the 5-HT7 receptor antagonist SB-269970 into the rat brainstem and basal forebrain: Site-dependent effects on REM sleep
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Microinjection of the 5-HT7 receptor antagonist SB-269970 into the rat brainstem and basal forebrain: Site-dependent effects on REM sleep

机译：5-HT7受体拮抗剂SB-269970显微注射到大鼠脑干和基底前脑：REM睡眠的部位依赖性效应

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摘要

The effects of SB-269970, a selective 5-HT7 receptor antagonist, on spontaneous sleep were studied in adult rats implanted for chronic sleep recordings. The 5-HT7 receptor ligand was microinjected into the horizontal limb of the diagonal band of Broca (HDB) and the laterodorsal tegmental nucleus (LDT) during the light period of the 12-h light/12-h dark cycle. For comparative purposes the compound was administered systemically and, in addition, injected directly into the dorsal raphe nucleus (DRN). Microinjection of SB-269970 into the HDB and the DRN induced a significant reduction of rapid-eye-movement sleep (REMS). Similar effects were observed after systemic administration of the 5-HT7 receptor antagonist. On the other hand, local infusion of the compound into the LDT provoked the opposite effect. It is proposed that the deactivation of GABAergic cells located in the HDB, DRN and LDT is responsible for the changes induced by SB-269970 on REM sleep values. It is suggested that the antidepressant effect of the 5-HT7 receptor antagonist could partly depend on the involvement of neuronal systems located in the DRN and the HDB.
机译：在植入有慢性睡眠记录的成年大鼠中研究了选择性5-HT7受体拮抗剂SB-269970对自发性睡眠的影响。在12小时光照/ 12小时黑暗周期的光照期间，将5-HT7受体配体显微注射到Broca对角带（HDB）的水平肢体和后背被盖核（LDT）中。为了比较目的，将该化合物全身给药，此外，直接注射到背沟核（DRN）中。将SB-269970微量注射到HDB和DRN中可显着减少快速眼动睡眠（REMS）。全身给药5-HT7受体拮抗剂后，观察到相似的效果。另一方面，将化合物局部输注到LDT中引起相反的效果。有人提出，位于HDB，DRN和LDT中的GABA能细胞失活是SB-269970引起的REM睡眠值变化的原因。建议5-HT7受体拮抗剂的抗抑郁作用可能部分取决于位于DRN和HDB中的神经元系统的参与。

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