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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Differential severity of anxiogenic effects resulting from a brief swim or underwater trauma in adolescent male rats
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Differential severity of anxiogenic effects resulting from a brief swim or underwater trauma in adolescent male rats

机译：青春期雄性大鼠短暂游泳或水下创伤引起的不同致焦虑作用

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Clinical studies have shown a link between early-life adversity and severity of adulthood responses to a traumatic stress event (post-traumatic stress disorder, PTSD). Despite a need for basic research, few rodent models are available to test the lasting impacts of early-life traumatic stressors. Underwater trauma (UWT) has been used previously to model traumatic stress; however, effects of this procedure have only been characterized in adulthood. Susceptibility of younger animals to physiological or psychological damage from a forced submersion procedure is unknown. A procedure involving swimming may be a stressful stimulus outside of the underwater component of the experience, as well. The acute effects of a 1-minute sham exposure (empty water tank), swim-only, and UWT (40 s swim followed by 20 s underwater) were compared in adolescent rats at postnatal day 37. No effects on blood oxygenation or lung tissue were observed. Stepwise decreases in open arm behavior were observed on the elevated plus maze (EPM) in swim-only rats, while UWT rats showed an immediate, lasting decrease in open arm behavior. UWT rats showed a significant decrease in basal corticosterone one week after trauma. These results show that while water immersion is a stressor, UWT causes a distinct syndrome of traumatic stress response in adolescent rats.
机译：临床研究表明，早期逆境与成年对创伤性应激事件（创伤后应激障碍，PTSD）的反应严重程度之间存在联系。尽管需要基础研究，但很少有啮齿动物模型可用于测试早期创伤性应激源的持久影响。水下创伤（UWT）以前曾被用来模拟创伤压力。然而，这种方法的效果仅在成年期才有特征。未知年轻动物对强迫潜水程序造成的生理或心理损害的敏感性。涉及游泳的程序也可能是体验的水下部分之外的压力刺激。在出生后第37天，对青春期大鼠进行了1分钟假暴露（空水箱），仅游泳和UWT（40 s游泳，然后在水下20 s）的急性作用进行了比较。对血氧或肺组织无影响被观察。在只游泳的大鼠中，在高架迷宫（EPM）上观察到张开臂行为的逐步降低，而UWT大鼠则显示出张开臂行为的立即，持久的降低。 UWT大鼠在创伤后一周显示基底皮质酮显着减少。这些结果表明，虽然水浸是应激源，但UWT会在青春期大鼠中引起明显的创伤性应激反应综合征。

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