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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of training dose on the relationship between discriminative-stimulus and self-reported drug effects of d-amphetamine in humans.
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Effects of training dose on the relationship between discriminative-stimulus and self-reported drug effects of d-amphetamine in humans.

机译：训练剂量对d-苯异丙胺的歧视性刺激与自我报告的药物作用之间的关系的影响。

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摘要

The aim of the present experiment was to examine the relationship between the discriminative-stimulus and self-reported effects of drugs in humans. To accomplish this aim, nine healthy adult volunteers (four females, five males) were trained to discriminate between placebo and 10 mg d-amphetamine (low-dose group) or 20 mg d-amphetamine (high-dose group). After acquiring the placebo-amphetamine discrimination, a range of doses of d-amphetamine (1.25-20 mg) was tested to determine if they shared discriminative stimulus effects with the training dose. Participants in the low-dose group exhibited a significant leftward shift in the dose-response function for discrimination performance, which is concordant with previous preclinical and human drug discrimination studies that assessed the effects of training dose. Consistent with the drug discrimination findings, participants in the low-dose group exhibited a significant leftward shift in the dose-response function for several self-reported drug effects (e.g., Like the Drug and Stimulated). However, several other self-reported drug effect items were not significantly influenced by training condition (e.g., Anxious/Nervous and Bad Effects). These results suggest that the discriminative-stimulus and self-reported drug effects of d-amphetamine overlap, but are not isomorphic. Furthermore, these results illustrate that behavioral history significantly influences subsequent drug effects in humans.
机译：本实验的目的是检验药物对人的歧视性刺激与自我报告效应之间的关系。为了实现这一目标，培训了九名健康的成人志愿者（四名女性，五名男性），以区分安慰剂和10毫克d-苯丙胺（低剂量组）或20毫克d-苯丙胺（高剂量组）。在获得安慰剂-苯丙胺的辨别力后，测试一系列剂量的d-苯丙胺（1.25-20 mg），以确定它们与训练剂量是否具有歧视性刺激作用。低剂量组的参与者对歧视表现的剂量反应功能表现出明显的左移，这与先前评估训练剂量效果的临床前和人类药物歧视研究一致。与药物歧视的发现一致，低剂量组的参与者对几种自我报告的药物作用（例如，像药物和刺激药物）表现出剂量反应功能的明显左移。但是，其他几个自我报告的药物疗效项目也不受训练条件的显着影响（例如，焦虑/神经和不良反应）。这些结果表明，d-苯异丙胺的判别刺激和自我报告的药物作用重叠，但不是同构的。此外，这些结果表明，行为史显着影响人类随后的药物作用。

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