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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Manipulation of central GABAergic and dopaminergic systems alters stress responding in the rat.
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Manipulation of central GABAergic and dopaminergic systems alters stress responding in the rat.

机译：中央GABA能和多巴胺能系统的操纵改变了大鼠的应激反应。

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Activation of central GABA(A) systems with muscimol has been shown to facilitate stress responding and GABA is known to modulate central dopaminergic activity. To evaluate the possibility that this effect of muscimol may depend upon a dopamine mechanism we have tested the effect of intracerebroventricular coadministration of muscimol and the selective D(1) antagonist SCH 23390 on behaviors evoked by tail pinch stress. When injected by themselves muscimol (1.75 nmol) facilitated stress-evoked oral behavior while SCH 23390 (6-600 nmol) produced a dose-related suppression of oral behavior. Coadministration of muscimol and doses of SCH 23390 selected for producing no (6 and 30 nmol), or marginal (60 nmol), effects on stress responding resulted in a dose-related reversal of the increase in orality seen with muscimol alone. The results are consistent with the notion that stressful stimuli activate central GABA(A) systems which, in turn, enhance dopaminergic neurotransmission.
机译：已显示用麝香酚激活中央GABA（A）系统可促进应激反应，并且已知GABA可调节中央多巴胺能活性。为了评估muscimol的这种作用可能取决于多巴胺机制的可能性，我们已经测试了muscimol和选择性D（1）拮抗剂SCH 23390的脑室内联合施用对尾巴捏应力诱发的行为的影响。当单独注射麝香酚（1.75 nmol）时，可促进压力诱发的口腔行为，而SCH 23390（6-600 nmol）则产生剂量相关的口腔行为抑制作用。 muscimol的共同给药和选择用于不产生（6和30 nmol）或边缘产生（60 nmol）的SCH 23390剂量对应激反应的作用导致单独使用muscimol所见的口服量增加的剂量相关逆转。结果与压力刺激激活中枢GABA（A）系统的观点相符，后者进而增强了多巴胺能神经传递。

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