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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Genetic, sex, and early environmental effects on the voluntary alcohol intake in Wistar rats.
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Genetic, sex, and early environmental effects on the voluntary alcohol intake in Wistar rats.

机译：Wistar大鼠自愿饮酒的遗传，性别和早期环境影响。

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摘要

The aim of this study was to investigate the effects of genetic, sex, and early environmental factors on the voluntary alcohol intake in Wistar rats. Genetic correlates were examined by comparing animals pharmacogenetically selected for high susceptibility to apomorphine (APO-SUS) with animals selected for low susceptibility (APO-UNSUS). Early environmental factors were investigated through postnatal manipulations (cross-fostering in APO-SUS and maternal deprivation in APO-UNSUS). Voluntary alcohol intake was measured using a two-bottle, free-choice protocol, in which animals could choose either water or an ascending series of alcohol concentrations every second day. Genetic correlates were only observed in male rats, with APO-UNSUS animals consuming more alcohol than APO-SUS animals. No effect of the early postnatal manipulations was detected: neither cross-fostering nor maternal deprivation influenced the voluntary alcohol intake. As for the influence of gender on ethanol self-administration, APO-SUS females consume more alcohol than APO-SUS males, while no sex differences were observed in APO-UNSUS animals.
机译：这项研究的目的是调查遗传，性别和早期环境因素对Wistar大鼠自愿饮酒的影响。通过比较在药物遗传学上选择对阿扑吗啡的敏感性高的动物（APO-SUS）与对敏感性低的动物（APO-UNSUS），对遗传相关性进行了检查。通过产后操作（APO-SUS中的交叉寄养和APO-UNSUS中的母体剥夺）调查了早期环境因素。使用两瓶自由选择方案测量自愿饮酒量，其中动物每两天可以选择水或一系列递增的酒精浓度。遗传相关性仅在雄性大鼠中观察到，APO-UNSUS动物比APO-SUS动物消耗更多的酒精。没有发现早期产后操作的效果：交叉养育和母亲剥夺都没有影响自愿饮酒。关于性别对乙醇自我管理的影响，APO-SUS雌性比APO-SUS雄性消耗更多的酒精，而在APO-UNSUS动物中未观察到性别差异。

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