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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Antipsychotic drugs and reproductive hormones: relationship to body weight regulation.
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Antipsychotic drugs and reproductive hormones: relationship to body weight regulation.

机译：抗精神病药和生殖激素：与体重调节的关系。

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Excessive body weight gain is an undesirable side effect of prolonged administration of antipsychotic drugs (AP), which affects health and interferes with treatment compliance. It has been suggested that hyperprolactinemia-induced endocrine and metabolic abnormalities, particularly in the gonadal steroids, might be involved in the development of this type of weight gain. To test this hypothesis, reproductive hormones, cortisol, dehydro-epiandrosterone-sulfate (DHEA-S), thyroid hormones, and body weight gain were assessed in 18 patients (9 men, 9 women) with mental disorders receiving AP who had been medication-free for at least 3 months before the study, and in 27 placebo-treated subjects (10 men, 17 women). In women, hormones were evaluated during several phases of the menstrual cycle. A significant weight gain was observed in men but not in women. Under AP administration, women displayed significantly lower serum levels of estradiol and progesterone, whereas in men the levels of free testosterone and DHEA-S were significantly lower than in controls. Hyperprolactinemia was observed in both sexes. The levels of follicle-stimulating hormone in women and luteinizing hormone in men were significantly elevated by treatment, thus suggesting that the functioning of the hypothalamus-pituitary gonads was preserved. In men, such an endocrine profile resembles that observed in subjects with primary obesity. Women under AP administration were found to be relatively hyperandrogenic because of decreased serum estradiol levels, whereas women with primary obesity are known to display actual increased levels of androgens. These endocrine abnormalities may contribute to the excessive weight gain observed after AP treatment, and these could be the target of novel pharmacological treatments.
机译：体重过度增加是长时间服用抗精神病药（AP）的不良副作用，会影响健康并干扰治疗依从性。已经表明，高泌乳素血症引起的内分泌和代谢异常，特别是在性腺类固醇中，可能与这种体重增加的发展有关。为了验证这一假设，我们对18例接受药物治疗且患有AP的精神障碍患者（其中9例男性，9例女性）的生殖激素，皮质醇，脱氢表雄酮硫酸盐（DHEA-S），甲状腺激素和体重增加进行了评估，在研究前至少3个月免费，并在27位接受安慰剂治疗的受试者中（10位男性，17位女性）免费服用。在女性中，在月经周期的多个阶段对激素进行了评估。男性体重显着增加，而女性则没有。在接受AP治疗后，女性的血清雌二醇和孕酮水平显着降低，而男性的游离睾丸激素和DHEA-S水平显着低于对照组。男女均观察到高泌乳素血症。通过治疗，女性的促卵泡激素水平和男性的促黄体生成激素水平显着升高，因此表明下丘脑-垂体性腺的功能得以保留。在男性中，这种内分泌特征类似于在原发性肥胖患者中观察到的内分泌特征。人们发现，接受AP治疗的女性由于血清雌二醇水平降低而相对雄激素过多，而已知患有原发性肥胖的女性表现出实际的雄激素水平升高。这些内分泌异常可能导致AP治疗后体重增加过多，这些可能成为新型药物治疗的目标。

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