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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Cocaine-induced oscillation is conditionable.
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Cocaine-induced oscillation is conditionable.

机译：可卡因引起的振荡是有条件的。

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摘要

We have recently shown that under some circumstances, sensitization produced by a stimulant such as cocaine (COC) can give way, with successive drug administrations, to alternating attenuations and reinstatements of the effect, an outcome that we have termed oscillation. Because sensitization to COC can be conditioned, we inquired whether COC-induced oscillation also was conditionable. The end point used was shock-induced hypoalgesia (paw withdrawal from a hot plate), as we have previously shown that oscillation follows initial sensitization of this measure with one to five pretreatments of 12 mg/kg (IP) of COC spaced at 1-week intervals, with the last COC injection occurring 30 min prior to the footshock. Experiment 1 indicated that a conditioned stimulus (CS)--a distinctive environment--which repeatedly had been paired with COC, would substitute for the last COC injection in sustaining the oscillatory effect. Experiment 2 showed that a previously established CS successfully substituted for all COC injections in first inducing sensitization that was then followed by oscillation. These findings strongly suggest that COC-induced oscillation shares with COC-induced sensitization, the property that both can be conditioned.
机译：我们最近已经表明，在某些情况下，通过连续服用药物，可卡因（COC）等兴奋剂产生的致敏作用可以交替减弱和恢复这种作用，我们将这种结果称为振荡。因为可以调节对COC的敏化作用，所以我们询问了COC诱导的振荡是否也是可调节的。所使用的终点是休克引起的痛觉过敏（从热板上拔出爪子），因为我们之前已经表明，此方法的初始敏化是通过对1至5个12 mg / kg（IP）的COC预处理进行间隔1到5个预处理后进行的。每周间隔一次，最后一次COC注射发生在休克前30分钟。实验1表明，反复与COC配对的条件刺激（CS）-一种独特的环境-可以代替最后一次COC注射来维持振荡效果。实验2表明，先前建立的CS成功地替代了所有COC注射剂，首先诱导了敏化作用，然后进行了振荡。这些发现强烈表明，COC诱导的振荡与COC诱导的敏化作用相同，两者均可调节。

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