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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Baclofen alters ethanol-stimulated activity but not conditioned place preference or taste aversion in mice.
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Baclofen alters ethanol-stimulated activity but not conditioned place preference or taste aversion in mice.

机译：巴氯芬可改变乙醇刺激的活性，但不会改变小鼠的条件性位置偏爱或口味厌恶。

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The present experiments examined the effects of the GABA(B) receptor agonist, baclofen, on the acquisition of ethanol-induced conditioned place preference (CPP) and conditioned taste aversion (CTA) in male DBA/2J mice. Mice in the CPP experiment received four pairings of ethanol (2g/kg) with a distinctive floor stimulus for a 5-min conditioning session (CS+ sessions). On intervening days (CS- sessions), mice received saline injections paired with a different floor type. On CS+ days, mice also received one of four doses of baclofen (0.0. 2.5, 5.0, or 7.5 mg/kg) 15 min before an injection of ethanol. For the preference test, all mice received saline injections, and were placed on a half-grid and half-hole floor for a 60-min session. Baclofen dose dependently reduced ethanol-stimulated activity, but did not alter the magnitude of ethanol-induced CPP at any dose. For the CTA experiment, mice were adapted to a 2-h per day water restriction regimen followed by five conditioning trials every 48 h. During conditioning trials, subjects received an injection of saline or baclofen (2.0 and 6.0 mg/kg) 15 min before injection of 2 g/kg ethanol or saline following 1-h access to a saccharin solution. Baclofen did not alter the magnitude of ethanol-induced CTA at any dose. In addition, baclofen alone did not produce a CTA. Overall, these studies show that activation of GABA(B) receptors with baclofen reduces ethanol-induced locomotor activation, but does not alter ethanol's rewarding or aversive effects in the CPP and CTA paradigms in DBA/2J mice.
机译：本实验检查了雄性DBA / 2J小鼠中GABA（B）受体激动剂巴氯芬对乙醇诱导的条件性位置偏好（CPP）和条件性味觉厌恶（CTA）的获取。在CPP实验中，小鼠接受了四对乙醇（2g / kg），并具有独特的地板刺激，持续5分钟（CS +阶段）。在中间的几天（CS-会议），小鼠接受盐水注射与不同的地板类型配对。在CS +天，小鼠在注射乙醇前15分钟还接受了四剂巴氯芬（0.0。2.5、5.0或7.5 mg / kg）中的一种。对于偏好测试，所有小鼠均接受盐水注射，并置于半网格半孔地板上60分钟。巴氯芬剂量依赖性地降低了乙醇刺激的活性，但在任何剂量下均未改变乙醇诱导的CPP的大小。对于CTA实验，将小鼠适应每天2小时的水限制方案，然后每48小时进行五次条件试验。在条件试验中，受试者在接受糖精溶液1小时后的15分钟内注射了盐水或巴氯芬（2.0和6.0 mg / kg），然后注射了2 g / kg的乙醇或盐水。巴氯芬在任何剂量下都不会改变乙醇诱导的CTA的幅度。此外，单独使用巴氯芬不能产生CTA。总体而言，这些研究表明，用巴氯芬激活GABA（B）受体可减少乙醇诱导的运动性激活，但不会改变乙醇对DBA / 2J小鼠的CPP和CTA范例的奖励或厌恶作用。

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