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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Ethanol modulates cocaine-induced behavioral change in inbred mice.
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Ethanol modulates cocaine-induced behavioral change in inbred mice.

机译：乙醇调节可卡因诱导的近交小鼠行为改变。

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We recently conducted a study of the behavioral effects of combined cocaine and ethanol in genetically defined mice. Male and female C57BL/6 (B6) and DBA/2 (D2) were tested in an automated activity monitor on 2 consecutive days. On day 1, all animals received an IP injection of sterile saline and were placed into the activity monitor for 30 min. Behaviors measured were total distance traveled, stereotypy, nosepokes, and wall-seeking. On day 2, all animals were tested again for 15 min following injection of one of the following: saline, 10% v/v ethanol at 2.0 g kg(-1) or 2.0 g kg(-1) ethanol plus 5, 15, or 30 mg kg(-1) cocaine. Cocaine alone at the same doses was injected into separate groups of animals. For the B6 strain, the overall effect of ethanol was to reduce cocaine-induced locomotor stimulation; no consistent effect of ethanol on cocaine-induced locomotion was observed in D2 mice. Cocaine-induced inhibition of nosepokes in both strains and sexes was partially reversed by ethanol. Ethanol also partially reversed cocaine-elevated stereotypy in both strains and both sexes. In B6 mice, cocaine-increased wall seeking tended to be reversed by coadministration of ethanol, whereas no consistent pattern was observed in the D2s. Results from this study suggest that the several measures affected by cocaine (locomotor activity, stereotypy, exploration, thigmotaxis) were, in turn, differentially affected by concurrent treatment with ethanol. Furthermore, our results point to genetic-based differences in ethanol's effects on cocaine-related behaviors. We address the implications for combined ethanol and cocaine use in humans.
机译：我们最近对可卡因和乙醇联合在基因定义的小鼠中的行为影响进行了研究。连续2天在自动活动监控器中测试了男性和女性C57BL / 6（B6）和DBA / 2（D2）。在第1天，所有动物接受IP注射的无菌盐水，并置于活动监测器中30分钟。所测量的行为是总行进距离，刻板印象，鼻塞和寻壁行为。在第2天，在注射以下任何一种药物后，再次对所有动物进行15分钟的测试：盐水，2.0 g kg（-1）的10％v / v乙醇或2.0 g kg（-1）乙醇加5、15或30 mg kg（-1）可卡因。将相同剂量的可卡因单独注射到不同的动物组中。对于B6菌株，乙醇的总体作用是减少可卡因诱导的运动刺激。在D2小鼠中未观察到乙醇对可卡因诱导的运动的一致作用。可卡因诱导的品系和性别对鼻涕的抑制被乙醇部分逆转。乙醇在两个菌株和两个性别中也部分逆转了可卡因升高的刻板印象。在B6小鼠中，可卡因增加的壁寻找趋向于被乙醇共同给药逆转，而在D2s中未观察到一致的模式。这项研究的结果表明，受可卡因影响的几种措施（运动能力，刻板印象，探索，触动）反过来受乙醇同时治疗的影响不同。此外，我们的研究结果指出乙醇对可卡因相关行为的影响基于遗传的差异。我们解决了乙醇和可卡因联合使用对人类的影响。

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