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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of LHRH on avoidance conditioning in normally cycling and ovariectomized female rats.
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Effects of LHRH on avoidance conditioning in normally cycling and ovariectomized female rats.

机译：LHRH对正常循环和卵巢切除雌性大鼠回避条件的影响。

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摘要

Several studies have demonstrated that the peptide LHRH can modify behavior in the male rat. Peripheral and intracerebral infusions of LHRH impair the acquisition of conditioned avoidance responses (CARs) and increase some spontaneous motor behaviors, such as head shaking and grooming. The present study was undertaken to detect the effects of LHRH on the acquisition of CARs and spontaneous motility in normally cycling and ovariectomized (OVX) Sprague-Dawley female rats. Normally cycling females were separated in four groups, according to the stage of the estrous cycle. Ovariectomized female rats were pretreated, 48 h before the experiment, with estradiol benzoate (10 microg/kg) or corn oil. LHRH (6.25, 25, or 50 microg/kg) was subcutaneously injected and the behavioral tests began 1 h after. Low doses of LHRH stimulated the acquisition of CARs during proestrus, estrus, and metestrus, whereas higher doses impaired conditioning in all the four stages of the cycle. High doses of LHRH impaired acquisition in OVX rats treated with oil and potentiated the depressant effects of EB on this behavior. The effects of LHRH on spontaneous motor activity were either stimulatory or inhibitory, according to the hormonal status and the dose administered. High doses of LHRH decreased motor responses in the diestrous rat. All the doses of LHRH increased the number of headshakes during proestrus, estrus, and metestrus, while the other motor responses were scarcely or not affected by LHRH in these stages. In OVX rats LHRH increased rearing, head shaking, and grooming behavior. These results support a role of LHRH in the modulation of conditioned and spontaneous behavior. They could provide an explanation to the behavioral changes observed across the estrous cycle and those observed after EB priming in OVX rats.
机译：多项研究表明，肽LHRH可以改变雄性大鼠的行为。 LHRH的周围和脑内输注会损害条件回避反应（CAR）的获取并增加一些自发的运动行为，例如摇头和修饰。进行本研究以检测LHRH对正常自行车和卵巢切除（OVX）Sprague-Dawley雌性大鼠中CAR的获取和自发运动的影响。正常情况下，根据发情周期的阶段，将骑自行车的女性分为四组。在实验前48小时，用雌二醇苯甲酸酯（10微克/千克）或玉米油预处理去卵巢的雌性大鼠。皮下注射LHRH（6.25、25或50 microg / kg），行为测试在1小时后开始。低剂量的LHRH在发情期，发情期和发情期刺激CAR的获得，而高剂量的LHRH则在周期的所有四个阶段都损害了调理能力。高剂量的LHRH损害了用油治疗的OVX大鼠的获取，并增强了EB对这种行为的抑制作用。根据激素状态和给药剂量，LHRH对自发运动活动的影响是刺激性的或抑制性的。高剂量的LHRH会降低雌性大鼠的运动反应。 LHRH的所有剂量均增加了在发情期，发情期和发情期的握手次数，而在这些阶段，其他运动反应几乎不受LHRH的影响或不受其影响。在OVX大鼠中，LHRH增加了饲养，摇头和修饰行为。这些结果支持LHRH在调节条件性和自发性行为中的作用。他们可以解释整个发情周期内观察到的行为变化以及在OVX大鼠中EB引发后观察到的行为变化。

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