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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Comparison of behavioral effects of moclobemide and deprenyl during forced swimming.
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Comparison of behavioral effects of moclobemide and deprenyl during forced swimming.

机译：强制游泳期间莫氯贝米和地戊二烯的行为影响比较。

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The present study compared the antiimmobility effects of l-deprenyl (DEP) and moclobemide (MOC) to the classic antidepressant imipramine (IMI), using an ethological approach. To investigate the degree of MAO-B inhibition by DEP and MOC, combination of treatments of ineffective doses of phenylethylamine (PHEA) with DEP or with MOC were administered in three doses before immobility was tested in the forced-swimming paradigm. Tests were videotape recorded for analysis of the frequency and duration of the behaviors during the procedure. There was a significant, dose-dependent decrease in immobility duration and an increase in mobility duration of rats treated with IMI. Both active behaviors of climbing and swimming were equally enhanced by the tricyclic antidepressant, climbing behavior composing 75% of the mobile behaviors. The intermediate doses of the MAOIs tested, DEP 0.25 mg/kg and MOC 30 mg/kg, decreased immobility and increased mobility. The antiimmobility effect of DEP was due to longer climbing behavior while MOC enhanced swimming duration. No behavioral changes were seen with the administration of the lower and higher doses of the MAOI. Potentiation of the antiimmobility effects was observed when ineffective doses of PHEA and of DEP or MOC were administered in combination. Differences between the MAO inhibitors on the active behaviors were also observed when administered with PHEA; DEP and PHEA significantly increased climbing and MOC and PHEA increased swimming. This preclinical evaluation of selective MAO inhibitors indicates that both MAO-A and MAO-B inhibitors have antidepressant effects. However, to clearly demonstrate that these antiimmobility effects are a consequence of increased brain concentrations of any one of the several monoamines implicated in the mechanism of action of DEP or MOC should be the subject of future studies.
机译：本研究使用一种行为学方法，比较了左旋异戊烯基（DEP）和莫氯贝米（MOC）与经典抗抑郁药丙咪嗪（IMI）的抗固定作用。为了研究DEP和MOC对MAO-B的抑制程度，在强制游泳范例中对不动性进行测试之前，将DEP或MOC对无效剂量的苯乙胺（PHEA）进行联合治疗，共分三剂进行。记录测试录像带，以分析手术过程中行为的频率和持续时间。用IMI治疗的大鼠的运动持续时间显着，剂量依赖性降低，并且运动持续时间增加。三环抗抑郁药会同时提高攀岩和游泳的活跃行为，其中攀岩行为占移动行为的75％。所测试的MAOI的中间剂量DEP 0.25 mg / kg和MOC 30 mg / kg，降低了固定性并增加了流动性。 DEP的抗固定作用是由于更长的攀爬行​​为，而MOC延长了游泳时间。较低和较高剂量的MAOI均未见行为改变。当联合使用无效剂量的PHEA和DEP或MOC时，观察到抗固定作用的增强。当与PHEA一起使用时，还观察到MAO抑制剂在活动行为上的差异。 DEP和PHEA显着增加了攀爬，而MOC和PHEA则增加了游泳。选择性MAO抑制剂的临床前评估表明，MAO-A和MAO-B抑制剂均具有抗抑郁作用。但是，为了清楚地证明这些抗固定作用是由于涉及DEP或MOC的作用机理的几种单胺中任一种的脑浓度升高而引起的，应作为未来研究的主题。

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