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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Hypothermic effects of dopamine D3 receptor agonists in the island of Calleja Magna. Potentiation by D1 activation.
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Hypothermic effects of dopamine D3 receptor agonists in the island of Calleja Magna. Potentiation by D1 activation.

机译：多巴胺D3受体激动剂在卡莱亚麦格纳岛的低温效应。通过D1激活增强作用。

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摘要

The selective functions of D3 receptors in the brain are still poorly understood, mainly because all the ligands active at dopamine D3 receptors have also a high affinity for the D2 receptors. However, it is possible to study selectively D3 receptor function because some brain structures, such as the islands of Calleja, contain D3 and not D2 receptors. The position of the island of Calleja Magna in the rat brain makes it possible to inject dopamine D3 ligands into the vicinity of these D3 receptors, and to study their behavioral role, with no concomitant action on D2 receptors. We studied the effects on body temperature and on locomotion of unilateral microinjections of D2/D3 receptors ligands into the island of Calleja Magna and into the adjacent nucleus accumbens. The results show that D3 agonists injected into the island of Calleja Magna decrease body temperature and that this effect is potentiated by simultaneous injection of the D1 agonist SKF 38393. D3 agonists have no effect on locomotor activity in the island of Calleja Magna. In the nucleus accumbens, the D3 agonists have only weak effects on body temperature, but, when associated with a D1 agonist, strongly stimulate locomotor activity. The effects on body temperature of unilateral microinjections of dopamine agonists into unilaterally dopamine-depleted animals are the same as those in nondepleted ones. This indicates that the D3 receptors are localized postsynaptically in the island of Calleja Magna.
机译：大脑中D3受体的选择性功能仍然知之甚少，主要是因为对多巴胺D3受体有活性的所有配体对D2受体也有很高的亲和力。但是，可以选择性地研究D3受体的功能，因为某些大脑结构（例如Calleja岛）包含D3受体，而不包含D2受体。 Calleja Magna岛在大鼠大脑中的位置可以将多巴胺D3配体注入这些D3受体附近，并研究其行为作用，而对D2受体没有伴随作用。我们研究了对体温和D2 / D3受体配体单侧显微注射入Calleja Magna岛和邻近伏隔核的运动的影响。结果表明，注入Calleja Magna岛的D3激动剂降低了体温，并且同时注入D1激动剂SKF 38393增强了这种作用。D3激动剂对Calleja Magna岛的运动能力没有影响。在伏伏核中，D3激动剂仅对体温产生微弱的影响，但与D1激动剂结合时会强烈刺激运动能力。单侧消耗多巴胺的动物单侧注射多巴胺激动剂对体温的影响与非消耗性动物相同。这表明D3受体突触后定位在Calleja Magna岛。

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