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首页> 外文期刊>Pharmaceutical Biology >Antihepatotoxic Effect of Punica granatum Acetone Extract Against Isoniazid- and Rifampicin-Induced Hepatotoxicity
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Antihepatotoxic Effect of Punica granatum Acetone Extract Against Isoniazid- and Rifampicin-Induced Hepatotoxicity

机译：石榴籽丙酮提取物对异烟肼和利福平诱导的肝毒性的抗肝毒性作用

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摘要

The current study investigated the effect of 70% acetone extract of Punica granatum L. (Punicaceae; pomegranate family) fruits on hepatic marker enzymes, antioxidants, and tissue peroxidative damage during isoniazid- and rifampicin-induced hepatotoxicity. Isoniazid and rifam-picin (each at doses of 50 mg/kg body weight, intraperi-toneally) for 15 days caused liver injury in rats that was manifested by significant elevation in the level of lipid peroxides, serum hepatic marker enzymes (glutamate oxaloacetate transaminase, glutamate pyruvate trans-aminase, lactate dehydrogenase, alkaline phosphatase), and by a significant decrease in the enzymic antioxidants (superoxide dismutase, catalase, glutathione S-transferase, glutathione peroxidase) and nonenzymic antioxidants (reduced glutathione, vitamin C, and vitamin E). Cotreat-ment with 70% acetone extract of Punica granatum fruits significantly prevented these alterations and restored the enzyme activities and lipid peroxides to near normalcy. These findings demonstrate the hepatoprotective potential of the acetone extract of Punica granatum fruits on tissue defense systems during isoniazid- and rifampicin-induced hepatotoxicity in rats.
机译：当前的研究调查了石榴（Punica granatum L。）（石榴科;石榴科）果实中70％丙酮提取物对异烟肼和利福平诱导的肝毒性过程中肝标志物酶，抗氧化剂和组织过氧化损伤的影响。异烟肼和rifam-picin（剂量分别为50 mg / kg体重，腹膜内）持续15天，引起大鼠肝损伤，其表现为脂质过氧化物，血清肝标志物酶（谷氨酸草酰乙酸转氨酶）水平明显升高。 ，谷氨酸丙酮酸转氨酶，乳酸脱氢酶，碱性磷酸酶），以及酶抗氧化剂（超氧化物歧化酶，过氧化氢酶，谷胱甘肽S-转移酶，谷胱甘肽过氧化物酶）和非酶抗氧化剂（还原型谷胱甘肽，维生素C和维生素E）的显着减少）。用石榴皮果实的70％丙酮提取物进行复配可显着防止这些改变，并将酶活性和脂质过氧化物恢复至接近正常水平。这些发现表明，在异烟肼和利福平诱导的大鼠肝毒性过程中，石榴籽丙酮提取物对组织防御系统具有保肝作用。

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