• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmaceutical Biology >Inhibition of tumor progression by naturally occurring terpenoids.
【24h】

Inhibition of tumor progression by naturally occurring terpenoids.

机译：天然萜类化合物抑制肿瘤进展。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CONTEXT: Cancer is a major public health problem in India and many other parts of the world. Its two main characteristics are uncontrolled cell growth and metastasis. Natural products represent a rich source of compounds that have found many applications in various fields of medicines and therapy including cancer therapy. Effective ingredients in several plant-derived medicinal extracts are terpenoid compounds and many terpenes have biological activities and are used for the treatment of human diseases. OBJECTIVES: This review attempted to collect all available published scientific literature of eight naturally occurring terpenoids and their effect on inhibition of tumor progression. METHODS: The present review is about eight potent naturally occurring terpenoids that have been studied for their pharmacological properties in our lab and this review includes 130 references compiled from all major databases. RESULTS: Literature survey revealed that triterpenoids, such as glycyrrhizic acid, ursolic acid, oleanolic acid, and nomilin, the diterpene andrographolide, and the monoterpenoids like limonene and perillic acid had shown immunomodulatory and antitumor activities. All of them could induce apoptosis in various cancer cells by activating various proapoptotic signaling cascades. Many of these terpenoids found to inhibit metastatic progression and tumor-induced angiogenesis. The molecular mechanisms that involved in these activities include inhibition of various oncogenic and anti-apoptotic signaling pathways and suppression or nuclear translocation of various transcription factors including nuclear factor kappa B (NF-kappaB). CONCLUSION: The chemopreventive and chemoprotective effects of these compounds point toward their possible role in modern anticancer therapies.
机译：背景：癌症是印度和世界许多其他地区的主要公共卫生问题。它的两个主要特征是不受控制的细胞生长和转移。天然产物代表了丰富的化合物来源，这些化合物已在包括癌症治疗在内的各种医学和治疗领域中找到了许多应用。几种植物来源的药用提取物中的有效成分是萜类化合物，许多萜具有生物活性，可用于治疗人类疾病。目的：本综述试图收集八种天然萜类化合物及其对肿瘤进展抑制作用的所有可用的已发表科学文献。方法：本综述是关于八种有效的天然萜类化合物，在我们的实验室中已对其药理特性进行了研究，该综述包括从所有主要数据库中收集的130篇参考文献。结果：文献调查显示，甘草酸，熊果酸，齐墩果酸和诺米林等三萜类化合物，双萜类穿心莲内酯，柠檬烯和紫苏酸等单萜类化合物均具有免疫调节和抗肿瘤活性。它们都可以通过激活各种促凋亡信号级联来诱导各种癌细胞的凋亡。发现许多这些萜类化合物抑制转移进程和肿瘤诱导的血管生成。参与这些活动的分子机制包括抑制各种致癌和抗凋亡信号传导途径，以及抑制或转录各种转录因子，包括核因子κB（NF-κB）。结论：这些化合物的化学预防和化学保护作用表明它们可能在现代抗癌治疗中发挥作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号