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首页> 外文期刊>Pharmaceutical Biology >Antibacterial activity in spices and local medicinal plants against clinical isolates of Karachi, Pakistan.
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Antibacterial activity in spices and local medicinal plants against clinical isolates of Karachi, Pakistan.

机译：香料和当地药用植物对巴基斯坦卡拉奇临床分离株的抗菌活性。

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CONTEXT: Development of resistance in human pathogens against conventional antibiotic necessitates searching indigenous medicinal plants having antibacterial property. Twenty-seven medicinal plants used actively in folklore, ayurvedic and traditional system of medicine were selected for the evaluation of their antimicrobial activity for this study. Eleven plants chosen from these 27 are used as spices in local cuisine. OBJECTIVE: Evaluation of the effectiveness of some medicinal plant extracts against clinical isolates. MATERIAL AND METHODS: Nonedible plant parts were extracted with methanol and evaporated in vacuo to obtain residue. Powdered edible parts were boiled three times and cooled in sterile distilled water for 2 min each and filtrate collected. The minimum inhibitory concentration (MIC) of plant extracts and filtrates/antibiotics was evaluated against clinical isolates by microbroth dilution method. RESULTS: Water extract of Syzygium aromaticum L. (Myrtaceae) buds, methanol extracts of Ficus carica L. (Moraceae) and Olea europaea L. (Oleaceae) leaves and Peganum harmala L. (Nitrariaceae) seeds had MIC ranges of 31.25-250 microg/ml. S. aromaticum inhibited growth of Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Salmonella enterica serovar Typhi and Pseudomonas aeruginosa. F. carica and O. europaea inhibited growth of S. aureus, S. epidermidis, and S. pyogenes whereas P. harmala was effective against S. aureus, Acinetobacter calcoaceticus and Candida albicans. Ampicillin, velosef, sulfamethoxazole, tetracycline and ceftazidime, cefotaxime, cefepime, which are used as control, had MIC >/= 50 and 1.5 microg/ml, respectively, for organisms sensitive to extracts. DISCUSSION AND CONCLUSION: Mono/multiextract from identified plants will provide an array of safe antimicrobial agents to control infections by drug-resistant bacteria.
机译：背景：人类病原体对常规抗生素的抗药性的发展有必要寻找具有抗菌特性的本土药用植物。选择了在民俗学，阿育吠陀学和传统医学体系中积极使用的27种药用植物，以评估其抗菌活性。从这27种植物中选择11种植物作为当地美食的香料。目的：评估一些药用植物提取物对临床分离株的有效性。材料与方法：将不可食用的植物部分用甲醇萃取，真空蒸发，得到残留物。将可食用粉状部分煮沸3次，并在无菌蒸馏水中冷却2分钟，并收集滤液。通过微肉汤稀释法，针对临床分离株评估了植物提取物和滤液/抗生素的最低抑菌浓度（MIC）。结果：蒲桃（Syzygiumaromaticum L。）（桃金娘科）芽的水提取物，无花果（Ficus carica L。）（桑科）和油橄榄（Olea europaea L.（Oleaceae））叶和Peganum harmala L.（Nitrariaceae）的甲醇提取物的MIC范围为31.25-250 microg /毫升。芳香链霉菌抑制金黄色葡萄球菌，表皮葡萄球菌，化脓性链球菌，小肠沙门氏菌血清型伤寒菌和铜绿假单胞菌的生长。 F. carica和O.europaea抑制金黄色葡萄球菌，表皮葡萄球菌和化脓性链球菌的生长，而harmala疟原虫对金黄色葡萄球菌，钙乙酸不动杆菌和白色念珠菌有效。氨苄青霉素，维洛塞夫，磺胺甲恶唑，四环素和头孢他啶，头孢噻肟，头孢吡肟用作对照，其对提取物敏感的微生物的MIC分别为> / = 50和1.5 microg / ml。讨论与结论：从鉴定出的植物中提取的单/多提取物将提供一系列安全的抗菌剂，以控制耐药菌的感染。

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