Antioxidant and Hepatoprotective Effects of Rosa damascena

C.R. Achuthan; B.H. Babu; J. Padikkala

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Antioxidant and Hepatoprotective Effects of Rosa damascena

机译：罗汉果的抗氧化和保肝作用

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The fresh juice of Rosa damascena Mill, flower exhibited promising in vitro antioxidant potential. The partially purified acetone fraction (AF) from silica gel column chromatography was found to be the active fraction with antioxidant properties. The AF required for 50% inhibition of superoxide radical production, hydroxyl radical generation and lipid peroxide formation were 13.75, 135 and 410 mug/ml, respectively. Oral administration of AF at 50mg/kg body weight significantly reduced the serum alkaline phosphatase (ALP), glutamine pyruvate transaminase (GPT) and glutamine oxaloacetate transaminase (GOT) activity and lipid peroxide level in rats receiving an acute dose of CC1_4. This indicated that R. damascena could protect against CC1_4 induced hepatotoxicity, possibly by its free radical scavenging activity.

机译：Rosa damascena Mill的新鲜果汁，花具有良好的体外抗氧化潜力。发现来自硅胶柱色谱的部分纯化的丙酮级分（AF）是具有抗氧化性能的活性级分。 50％抑制超氧化物自由基产生，羟基自由基产生和脂质过氧化物形成所需的AF分别为13.75、135和410杯/毫升。在口服CC1_4的大鼠中，以50mg / kg体重口服AF可以显着降低其血清碱性磷酸酶（ALP），谷氨酰胺丙酮酸转氨酶（GPT）和谷氨酰胺草酰乙酸转氨酶（GOT）的活性以及脂质过氧化水平。这表明大马士革可能通过其自由基清除活性来防御CC1_4诱导的肝毒性。

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《Pharmaceutical Biology》 |2003年第5期|共5页
作者
C.R. Achuthan; B.H. Babu; J. Padikkala;
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正文语种 eng
中图分类药学;
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Alkaline phosphatase; antioxidant; glutamine pyruvate transaminase; glutamine oxaloacetate transaminase; hepatoprotection; hydroxyl radical; lipid peroxidation; super-oxide radical.;

机译：碱性磷酸酶;抗氧化剂;谷氨酰胺丙酮酸转氨酶;谷氨酰胺草酰乙酸转氨酶;肝保护;羟基自由基;脂质过氧化;超氧化物自由基。;

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Antioxidant and Hepatoprotective Effects of Rosa damascena

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