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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Early ontogeny of D-amphetamine-induced one-trial behavioral sensitization.
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Early ontogeny of D-amphetamine-induced one-trial behavioral sensitization.

机译：D-苯丙胺诱导的一审行为敏化的早期个体发育。

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The early ontogeny of D-amphetamine-induced one-trial behavioral sensitization was characterized using male and female preweanling and preadolescent rats. In Experiment 1, rats were injected with saline or D-amphetamine (1, 4, or 8mg/kg) in activity chambers or the home cage on postnatal day (PD) 12, PD 16, PD 20, or PD 24. One day later, rats were challenged with either 0.5 or 2mg/kg D-amphetamine and distance traveled was measured in activity chambers for 120min. In Experiment 2, saline or D-amphetamine was administered in activity chambers on PD 24, while a challenge injection of D-amphetamine (0.25-4mg/kg) was given on PD 25. At younger ages (PD 13 and PD 17), a strong sensitized response was evident on the test day regardless of whether rats were pretreated with D-amphetamine (4 or 8mg/kg) before being placed in the activity chamber or 30min after being returned to the home cage. Rats did not display D-amphetamine-induced behavioral sensitization on PD 21, nor was context-dependent sensitization apparent on PD 25 even when a broad dose range of D-amphetamine was used. When low doses of D-amphetamine were administered on the pretreatment and test days (1 and 0.5mg/kg, respectively), sensitized responding was not evident at any age. In summary, D-amphetamine-induced one-trial behavioral sensitization was only apparent within a narrow developmental window during early ontogeny. This ontogenetic pattern of sensitized responding is similar to the one produced by methamphetamine and distinct from the pattern produced by cocaine. The unique sensitization profiles resulting from repeated D-amphetamine and cocaine treatment may be a consequence of their different mechanisms of action.
机译：使用雄性和雌性断奶前和青春期前的大鼠来表征D-苯丙胺诱导的一次试验行为敏化的早期个体发育。在实验1中，在出生后第12天，PD 16，PD 20或PD 24的活动室或家庭笼子中，给大鼠注射生理盐水或D-苯异丙胺（1、4、8 mg / kg）。之后，用0.5或2mg / kg D-苯丙胺攻击大鼠，并在活动室内测量120分钟的行进距离。在实验2中，在PD 24的活动室内注射了盐水或D-苯异丙胺，而在PD 25上进行了D-苯异丙胺的挑战性注射（0.25-4mg / kg）。在较年轻的年龄（PD 13和PD 17），在试验当天，无论是否将D-苯异丙胺（4 mg / kg或8mg / kg）放入活动室之前或将其放回笼子中30min之前，大鼠均会出现强烈的过敏反应。即使使用了大剂量的D-苯异丙胺，大鼠也没有在PD 21上表现出D-苯丙胺诱导的行为致敏作用，在PD 25上也没有明显的上下文相关致敏作用。当在预处理和测试日服用低剂量的D-苯异丙胺（分别为1和0.5mg / kg）时，在任何年龄段均没有明显的敏化反应。总之，D-苯丙胺诱导的一审行为敏化仅在个体发育早期的狭窄发育窗口内可见。致敏反应的这种个体发生模式与甲基苯丙胺产生的模式相似，与可卡因产生的模式不同。重复的D-苯丙胺和可卡因治疗产生的独特的致敏特征可能是其不同作用机理的结果。

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