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首页> 外文期刊>Pharmacopsychiatry >Imbalance between pro- and anti-inflammatory cytokines, and between Th1 and Th2 cytokines in depressed patients: the effect of electroacupuncture or fluoxetine treatment.
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Imbalance between pro- and anti-inflammatory cytokines, and between Th1 and Th2 cytokines in depressed patients: the effect of electroacupuncture or fluoxetine treatment.

机译：抑郁症患者的促炎和抗炎细胞因子之间以及Th1和Th2细胞因子之间的失衡：电针或氟西汀治疗的效果。

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BACKGROUND: An increase in inflammatory response and an imbalance between T-helper (Th) 1 and 2 functions have been implicated in major depression. The aims of the present study were to 1) study the relationship between pro- and anti-inflammatory cytokines and between Th1 and Th2 produced cytokines in depressed patients and 2) evaluate and compare the effect of treatments with electroacupuncture (EA) and fluoxetine on these cytokines. METHODS: 95 outpatients with major depressive disorder were treated for 6 weeks with EA, fluoxetine or placebo. Hamilton Depression Rating Scale (HDRS) and Clinical Global Impression (CGI) were used to assess severity and therapeutic effects. 30 volunteers served as controls. Serum cytokine concentrations were measured by ELISA. RESULTS: Increased proinflammatory cytokine interleukin (IL)-1beta and decreased anti-inflammatory cytokine IL-10 were found in the depressed patients. By contract, Th1 produced proinflammatory cytokines, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma were decreased, and Th2 produced cytokine IL-4 was significantly increased in depressed patients. The ratio of IFN/IL-4 was also increased. Both acupuncture and fluoxetine treatments, but not the placebo, reduced IL-1beta concentrations in responders. However, only acupuncture attenuated TNF-alpha concentration and INF-gamma/IL-4 ratio towards the control level. DISCUSSION: These results suggest that an imbalance between the pro- and anti-inflammatory cytokines (IL-1 and IL-10), and between Th1 and Th2 cytokines (INF-gamma or TNF-alpha and IL-4) occurred in untreated depressed patients. Both EA and fluoxetine had an anti-inflammatory effect by reducing IL-1beta. EA treatment also restored the balance between Th1 and Th2 systems by increasing TNF-alpha and decreasing IL-4.
机译：背景：炎性反应的增加以及T-helper（Th）1和2功能之间的失衡与严重抑郁症有关。本研究的目的是：1）研究抑郁症患者促炎和抗炎细胞因子之间的关系以及Th1和Th2产生的细胞因子之间的关系; 2）评价和比较电针（EA）和氟西汀的治疗效果细胞因子。方法：对95例重度抑郁症门诊患者进行EA，氟西汀或安慰剂治疗6周。汉密尔顿抑郁量表（HDRS）和临床总体印象（CGI）用于评估严重程度和治疗效果。 30名志愿者作为对照。通过ELISA测量血清细胞因子浓度。结果：发现抑郁症患者的促炎细胞因子白介素（IL）-1β升高，抗炎细胞因子IL-10降低。根据合同，在抑郁症患者中，Th1产生促炎细胞因子，肿瘤坏死因子（TNF）-α和干扰素（IFN）-γ降低，Th2产生的细胞因子IL-4显着增加。 IFN / IL-4的比例也增加了。针灸和氟西汀治疗均能降低应答者的IL-1β浓度，但安慰剂则不能。但是，只有针灸才能使TNF-α浓度和INF-γ/ IL-4比例降低至对照水平。讨论：这些结果表明，未经治疗的抑郁症患者的促炎和抗炎细胞因子（IL-1和IL-10）之间以及Th1和Th2细胞因子（INF-γ或TNF-α和IL-4）之间不平衡。耐心。 EA和氟西汀都通过降低IL-1β具有抗炎作用。 EA治疗还通过增加TNF-α和降低IL-4来恢复Th1和Th2系统之间的平衡。

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