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首页> 外文期刊>Physics in medicine and biology. >An x-ray image guidance system for small animal stereotactic irradiation.
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An x-ray image guidance system for small animal stereotactic irradiation.

机译：用于小动物立体定向照射的X射线图像引导系统。

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摘要

An x-ray image-guided small animal stereotactic irradiator was developed and characterized to enable tumor visualization and accurate target localization for small field, high dose irradiation. The system utilizes a custom collimation system, a motorized positioning system (x, y, theta), a digital imaging panel and operating software, and is integrated with a commercial x-ray unit. The essential characteristics of the irradiator include small radiation fields (1-10 mm), high dose rate (>10 Gy min(-1)) and submillimeter target localization. The software enables computer-controlled image acquisition, stage motion and target localization providing simple and precise automated target localization. The imaging panel was characterized in terms of signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and spatial resolution. Overall localization accuracy and precision were assessed. SNR, CNR and spatial resolution are 24 dB, 21 dB and 2.8 lp mm(-1), respectively, and localization accuracy is approximately 65 microm with 6 microm precision. With the aid of image guidance, system performance was subsequently used to evaluate radiation response in a rat orthotopic lung tumor effectively sparing normal tissues and in a mouse normal lung. The capabilities of 3D treatment and cone-beam computed tomography are presented for 3D localization and delivery as a work in progress.
机译：开发了一种X射线图像引导的小动物立体定向辐照器，并对其进行了表征，以实现肿瘤可视化和针对小视野，高剂量辐照的精确目标定位。该系统利用定制的准直系统，电动定位系统（x，y，θ），数字成像面板和操作软件，并与商业X射线装置集成在一起。辐射器的基本特征包括小的辐射场（1-10毫米），高剂量率（> 10 Gy min（-1））和亚毫米级目标定位。该软件可实现计算机控制的图像采集，平台运动和目标定位，从而提供简单而精确的自动化目标定位。成像面板的特征在于信噪比（SNR），对比噪声比（CNR）和空间分辨率。总体定位精度和精度进行了评估。 SNR，CNR和空间分辨率分别为24 dB，21 dB和2.8 lp mm（-1），定位精度约为65微米，精度为6微米。借助图像指导，系统性能随后被用于评估有效保留正常组织的鼠原位肺肿瘤和小鼠正常肺中的放射反应。正在进行中的3D定位和交付3D处理和锥形束计算机断层扫描的功能。

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