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首页> 外文期刊>Philosophical transactions of the Royal Society. Mathematical, physical, and engineering sciences >Conditional symbolic analysis detects nonlinear influences of respiration on cardiovascular control in humans
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Conditional symbolic analysis detects nonlinear influences of respiration on cardiovascular control in humans

机译：条件符号分析检测呼吸对人类心血管控制的非线性影响

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摘要

We propose a symbolic analysis framework for the quantitative characterization of complex dynamical systems. It allows the description of the time course of a single variable, the assessment of joint interactions and an analysis triggered by a conditioning input. The framework was applied to spontaneous variability of heart period (HP), systolic arterial pressure (SAP) and integrated muscle sympathetic nerve activity (MSNA) with the aim of characterizing cardiovascular control and nonlinear influences of respiration at rest in supine position, during orthostatic challenge induced by 80 degrees head-up tilt (TILT) and about 3 min before evoked pre-syncope signs (PRESY). The approach detected (i) the exaggerated sympathetic modulation and vagal withdrawal from HP variability and the increased presence of fast MSNA variability components during PRESY compared with TILT; (ii) the increase of the SAP-HP coordination occurring at slow temporal scales and a decrease of that occurring at faster time scales during PRESY compared with TILT; (iii) the reduction of the coordination between fast MSNA and SAP patterns during TILT and PRESY; (iv) the nonlinear influences of respiration leading to an increased likelihood to observe the abovementioned findings during expiration compared with inspiration one. The framework provided simple, quantitative indexes able to distinguish experimental conditions characterized by different states of the autonomic nervous system and to detect the early signs of a life threatening situation such as postural syncope.
机译：我们提出了一个符号分析框架，用于复杂动力学系统的定量表征。它允许描述单个变量的时间过程，评估关节相互作用以及由条件输入触发的分析。该框架适用于心律周期（HP），收缩期动脉压（SAP）和综合性肌肉交感神经活动（MSNA）的自发变异，旨在表征体位性挑战期间仰卧位静息时的心血管控制和呼吸的非线性影响在诱发晕厥前征兆（PRESY）之前约3分钟，由80度抬头倾斜（TILT）引起。该方法检测到：（i）与TILT相比，在PRESY中HP变异性夸大了交感调制和迷走神经退缩，以及快速MSNA变异性成分的存在增加; （ii）与TILT相比，在PRESY期间，在缓慢的时间尺度上发生的SAP-HP协调性增加，在更快的时间尺度上发生的SAP-HP协调性下降; （iii）在TILT和PRESY期间减少快速MSNA和SAP模式之间的协调; （iv）与吸气一相比，呼吸的非线性影响导致在呼气期间观察上述发现的可能性增加。该框架提供了简单，定量的指标，这些指标能够区分以植物神经系统不同状态为特征的实验条件，并能够检测危及生命的情况（如姿势性晕厥）的早期征兆。

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