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首页> 外文期刊>Physics in medicine and biology. >Simulation of temperature field for temperature-controlled radio frequency ablation using a hyperbolic bioheat equation and temperature-varied voltage calibration: a liver-mimicking phantom study
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Simulation of temperature field for temperature-controlled radio frequency ablation using a hyperbolic bioheat equation and temperature-varied voltage calibration: a liver-mimicking phantom study

机译：使用双曲生物热方程和温度可变电压校准对温度控制的射频消融的温度场进行模拟：仿肝模型研究

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This study aims at improving the accuracy of temperature simulation for temperature-controlled radio frequency ablation (RFA). We proposed a new voltage-calibration method in the simulation and investigated the feasibility of a hyperbolic bioheat equation (HBE) in the RFA simulation with longer durations and higher power. A total of 40 RFA experiments was conducted in a liver-mimicking phantom. Four mathematical models with multipolar electrodes were developed by the finite element method in COMSOL software: HBE with/without voltage calibration, and the Pennes bioheat equation (PBE) with/without voltage calibration. The temperature-varied voltage calibration used in the simulation was calculated from an experimental power output and temperature-dependent resistance of liver tissue. We employed the HBE in simulation by considering the delay time tau of 16 s. First, for simulations by each kind of bioheat equation (PBE or HBE), we compared the differences between the temperature-varied voltage-calibration and the fixed-voltage values used in the simulations. Then, the comparisons were conducted between the PBE and the HBE in the simulations with temperature-varied voltage calibration. We verified the simulation results by experimental temperature measurements on nine specific points of the tissue phantom. The results showed that: (1) the proposed voltage-calibration method improved the simulation accuracy of temperature-controlled RFA for both the PBE and the HBE, and (2) for temperature-controlled RFA simulation with the temperature-varied voltage calibration, the HBE method was 0.55 degrees C more accurate than the PBE method. The proposed temperature-varied voltage calibration may be useful in temperature field simulations of temperature-controlled RFA. Besides, the HBE may be used as an alternative in the simulation of long-duration high-power RFA.
机译：这项研究旨在提高温度控制射频消融（RFA）温度模拟的准确性。我们在仿真中提出了一种新的电压校准方法，并研究了双曲线生物热方程（HBE）在更长持续时间和更高功率的RFA仿真中的可行性。在模仿肝脏的模型中进行了40次RFA实验。通过COMSOL软件中的有限元方法，开发了四个带有多极电极的数学模型：带/不带电压校准的HBE和带/不带电压校准的Pennes生物热方程（PBE）。根据实验输出功率和肝脏组织的温度依赖性电阻，计算出模拟中使用的温度可变电压校准。考虑到延迟时间tau为16 s，我们在仿真中采用了HBE。首先，对于每种生物热方程（PBE或HBE）进行的模拟，我们比较了温度可变电压校准和模拟中使用的固定电压值之间的差异。然后，在具有温度可变电压校准的仿真中，对PBE和HBE进行了比较。我们通过对组织体模的九个特定点进行实验温度测量来验证仿真结果。结果表明：（1）提出的电压校准方法提高了PBE和HBE的温度控制RFA的仿真精度，以及（2）使用温度可变电压校准的温度控制RFA仿真， HBE方法比PBE方法精确0.55摄氏度。建议的温度可变电压校准在温度受控的RFA的温度场模拟中可能有用。此外，HBE可以用作长期大功率RFA仿真的替代方案。

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