...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physics in medicine and biology. >Effect of organ size and position on out-of-field dose distributions during radiation therapy.
【24h】

Effect of organ size and position on out-of-field dose distributions during radiation therapy.

机译：放射治疗期间器官大小和位置对场外剂量分布的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mantle field irradiation has historically been the standard radiation treatment for Hodgkin lymphoma. It involves treating large regions of the chest and neck with high doses of radiation (up to 30 Gy). Previous epidemiological studies on the incidence of second malignancies following radiation therapy for Hodgkin lymphoma have revealed an increased incidence of second tumors in various organs, including lung, breast, thyroid and digestive tract. Multiple other studies, including the Surveillance, Epidemiology and End Results, indicated an increased incidence in digestive tract including stomach cancers following mantle field radiotherapy. Assessment of stomach dose is challenging because the stomach is outside the treatment field but very near the treatment border where there are steep dose gradients. In addition, the stomach can vary greatly in size and position. We sought to evaluate the dosimetric impact of the size and variable position of the stomach relative to the field border for a typical Hodgkin lymphoma mantle field irradiation. The mean stomach dose was measured using thermoluminescent dosimetry for nine variations in stomach size and position. The mean doses to the nine stomach variations ranged from 0.43 to 0.83 Gy when 30 Gy was delivered to the treatment isocenter. Statistical analyses indicated that there were no significant differences in the mean stomach dose when the stomach was symmetrically expanded up to 3 cm or shifted laterally (medial, anterior or posterior shifts) by up to 3 cm. There was, however, a significant (P > 0.01) difference in the mean dose when the stomach was shifted superiorly or inferiorly by >/=2.5 cm.
机译：历史上，套膜场照射是霍奇金淋巴瘤的标准放射治疗。它涉及用高剂量的放射线（高达30 Gy）治疗胸部和颈部的大部分区域。先前对霍奇金淋巴瘤放疗后第二恶性肿瘤发生率的流行病学研究表明，在包括肺，乳腺，甲状腺和消化道在内的各种器官中，第二恶性肿瘤的发生率增加。包括监测，流行病学和最终结果在内的多项其他研究表明，地幔野放疗后消化道（包括胃癌）的发生率增加。胃剂量的评估具有挑战性，因为胃在治疗区域之外，但非常靠近剂量梯度陡峭的治疗边界。另外，胃的大小和位置可能有很大差异。我们试图评估典型的霍奇金淋巴瘤套膜野外照射对胃的大小和相对于野外边界的可变位置的剂量学影响。使用热发光剂量测定法测量胃的平均剂量，以测定胃的大小和位置的九种变化。当将30 Gy递送至治疗等中心点时，九种胃部变化的平均剂量范围为0.43至0.83 Gy。统计分析表明，当胃对称地扩张至3 cm或横向向内（向内，向前或向后移动）最多3 cm时，平均胃剂量没有显着差异。但是，当胃部上下移动> / = 2.5 cm时，平均剂量存在显着差异（P> 0.01）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号