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首页> 外文期刊>Physics in medicine and biology. >Multiple scattering effects in Doppler optical coherence tomography of flowing blood
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Multiple scattering effects in Doppler optical coherence tomography of flowing blood

机译：流血多普勒光学相干断层扫描中的多重散射效应

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摘要

We investigate the effect of multiple scattering on the optical coherence tomography (OCT) signal and the Doppler OCT signal of flowing blood. Doppler OCT measurements at 1300 nm are performed on flowing diluted porcine blood with hematocrit ranging between 0% and 15%. Measured blood hematocrit and mean red blood cell volume are used to calculate, using the discrete dipole approximation model, the (single) scattering coefficient and scattering anisotropy of blood. Monte Carlo simulations, based on the calculated scattering coefficients and scattering anisotropies, are compared to Doppler OCT measurements for hematocrit smaller than 10%. Good quantitative agreement between Doppler OCT measurements and Monte Carlo simulations is observed. Our measurements, calculations and simulations explain the relatively low attenuation coefficients and well preserved flow profiles measured with Doppler OCT for flowing blood. Monte Carlo simulations demonstrate the effect of the scattering anisotropy of the medium on the strength of multiple scattering effects in Doppler OCT signals. With increasing scattering anisotropy the OCT attenuation decreases; the distortion of the flow profile is strongest at intermediate scattering anisotropies (0.6).
机译：我们研究了多次散射对流动血液的光学相干断层扫描（OCT）信号和多普勒OCT信号的影响。在流动的稀释猪血中，血细胞比容在0％到15％之间进行1300 nm处的多普勒OCT测量。使用离散偶极近似模型，使用测得的血细胞比容和平均红细胞体积计算血液的（单个）散射系数和散射各向异性。将基于计算的散射系数和散射各向异性的蒙特卡罗模拟与血细胞比容小于10％的多普勒OCT测量进行比较。观察到多普勒OCT测量与蒙特卡洛模拟之间的良好定量一致性。我们的测量，计算和模拟解释了使用多普勒OCT测量的流动血液的相对较低的衰减系数和保存良好的血流曲线。蒙特卡洛模拟证明了介质的散射各向异性对多普勒OCT信号中多重散射效应强度的影响。随着散射各向异性的增加，OCT衰减会降低。在中间散射各向异性（0.6）时，流动剖面的变形最强。

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