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首页> 外文期刊>Physics in medicine and biology. >An image-based skeletal dosimetry model for the ICRP reference adult male--internal electron sources.
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An image-based skeletal dosimetry model for the ICRP reference adult male--internal electron sources.

机译：基于图像的骨架剂量模型，用于ICRP参考成年男性-内部电子源。

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In this study, a comprehensive electron dosimetry model of the adult male skeletal tissues is presented. The model is constructed using the University of Florida adult male hybrid phantom of Lee et al (2010 Phys. Med. Biol. 55 339-63) and the EGSnrc-based Paired Image Radiation Transport code of Shah et al (2005 J. Nucl. Med. 46 344-53). Target tissues include the active bone marrow, associated with radiogenic leukemia, and total shallow marrow, associated with radiogenic bone cancer. Monoenergetic electron emissions are considered over the energy range 1 keV to 10 MeV for the following sources: bone marrow (active and inactive), trabecular bone (surfaces and volumes), and cortical bone (surfaces and volumes). Specific absorbed fractions are computed according to the MIRD schema, and are given as skeletal-averaged values in the paper with site-specific values reported in both tabular and graphical format in an electronic annex available from http://stacks.iop.org/0031-9155/56/2309/mmedia. The distribution of cortical bone and spongiosa at the macroscopic dimensions of the phantom, as well as the distribution of trabecular bone and marrow tissues at the microscopic dimensions of the phantom, is imposed through detailed analyses of whole-body ex vivo CT images (1 mm resolution) and spongiosa-specific ex vivo microCT images (30 microm resolution), respectively, taken from a 40 year male cadaver. The method utilized in this work includes: (1) explicit accounting for changes in marrow self-dose with variations in marrow cellularity, (2) explicit accounting for electron escape from spongiosa, (3) explicit consideration of spongiosa cross-fire from cortical bone, and (4) explicit consideration of the ICRP's change in the surrogate tissue region defining the location of the osteoprogenitor cells (from a 10 microm endosteal layer covering the trabecular and cortical surfaces to a 50 microm shallow marrow layer covering trabecular and medullary cavity surfaces). Skeletal-averaged values of absorbed fraction in the present model are noted to be very compatible with those weighted by the skeletal tissue distributions found in the ICRP Publication 110 adult male and female voxel phantoms, but are in many cases incompatible with values used in current and widely implemented internal dosimetry software.
机译：在这项研究中，提出了成年男性骨骼组织的综合电子剂量学模型。使用Lee等（2010 Phys.Med.Biol.55339-63）的佛罗里达大学成年男性杂种体模和Shah等（2005 J.Nucl。 Med.46 344-53）。靶组织包括与放射性白血病有关的活动性骨髓和与放射性骨癌有关的全浅骨髓。对于以下来源，认为单能电子发射在1 keV至10 MeV的能量范围内：骨髓（有功和无功），小梁骨（表面和体积）和皮质骨（表面和体积）。根据MIRD方案计算特定的吸收分数，并在论文中以骨骼平均值的形式给出，并以表格和图形格式在电子附件中报告特定位置的值，该附件可从http://stacks.iop.org/获得。 0031-9155 / 56/2309 / mmedia。通过对全身离体CT图像（1 mm）进行详细分析，可以得出模型的宏观尺寸上的皮质骨和海绵体的分布，以及模型的微观尺寸上的小梁骨和骨髓组织的分布。分辨率）和海绵体特定的离体microCT图像（分辨率为30 microm），分别取自40岁的男性尸体。在这项工作中使用的方法包括：（1）明确考虑骨髓自身剂量随骨髓细胞密度的变化，（2）明确考虑从海绵状海绵体中逸出的电子，（3）明确考虑海绵状海绵体从皮质骨的交叉燃烧（4）明确考虑ICRP在代表骨祖细胞位置的替代组织区域的变化（从覆盖小梁和皮质表面的10微米内膜层到覆盖小梁和髓腔表面的50微米浅骨髓层） 。注意到本模型中吸收分数的骨骼平均值与通过ICRP出版物110成年男性和女性体素体模中的骨骼组织分布加权的值非常兼容，但在许多情况下与当前和人体模型中使用的值不兼容。广泛实施的内部剂量测定软件。

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