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Fixed number of segments in unidirectional decompositions of fluence matrices for step-and-shoot IMRT.

机译:步调射击IMRT的注量矩阵单向分解中的固定段数。

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The decomposition of a fluence matrix in step-and-shoot mode for intensity-modulated radiation therapy (IMRT) usually yields a large number of segments (NS) and, consequently, treatment time is substantially increased. In this paper, we propose a method for reducing the original NS in multileaf collimator segmentations to a user-specified quantity. The proposed method clusters original segments into the same number of groups as desired NS, and computes for each group an equivalent segment and an associated weight. In order to avoid important changes in dose-volume histograms (DVHs), equivalent segments and weights are computed taking into account the original fluence matrix and preserving the highest fluence zones, thus staying as close as possible to the original planned radiation. The method is applicable to unidirectional segmentations, where there is no backtracking of leaves, since this property facilitates the grouping of segments. The experiments showed that treatment times can be considerably reduced, while maintaining similar DVHs and dosimetric indexes. Furthermore, the algorithm achieved an excellent reduction/dose-quality ratio since the final NS was close to that reported for direct step-and-shoot solutions.
机译:对于强度调制放射治疗(IMRT),分步模式下的注量矩阵分解通常会产生大量的段(NS),因此,治疗时间会大大增加。在本文中,我们提出了一种将多叶准直仪分割中的原始NS减少到用户指定数量的方法。所提出的方法将原始段聚类为与所需NS相同数量的组,并为每个组计算等效段和关联的权重。为了避免剂量-体积直方图(DVHs)发生重要变化,在计算等效段和权重时要考虑原始的注量矩阵并保留最高的注量区,从而尽可能地接近原始的计划辐射。该方法适用于没有叶子回溯的单向分段,因为此属性有助于分段的分组。实验表明,在保持相似的DVH和剂量学指标的同时,可以大大减少治疗时间。此外,该算法实现了出色的降低/剂量质量比,因为最终的NS接近直接分步拍​​摄解决方案的报告。

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