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首页> 外文期刊>Physics in medicine and biology. >Physical and clinical performance of the mCT time-of-flight PET/CT scanner.
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Physical and clinical performance of the mCT time-of-flight PET/CT scanner.

机译：mCT飞行时间PET / CT扫描仪的物理和临床性能。

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摘要

Time-of-flight (TOF) measurement capability promises to improve PET image quality. We characterized the physical and clinical PET performance of the first Biograph mCT TOF PET/CT scanner (Siemens Medical Solutions USA, Inc.) in comparison with its predecessor, the Biograph TruePoint TrueV. In particular, we defined the improvements with TOF. The physical performance was evaluated according to the National Electrical Manufacturers Association (NEMA) NU 2-2007 standard with additional measurements to specifically address the TOF capability. Patient data were analyzed to obtain the clinical performance of the scanner. As expected for the same size crystal detectors, a similar spatial resolution was measured on the mCT as on the TruePoint TrueV. The mCT demonstrated modestly higher sensitivity (increase by 19.7 +/- 2.8%) and peak noise equivalent count rate (NECR) (increase by 15.5 +/- 5.7%) with similar scatter fractions. The energy, time and spatial resolutions for a varying single count rate of up to 55 Mcps resulted in 11.5 +/- 0.2% (FWHM), 527.5 +/- 4.9 ps (FWHM) and 4.1 +/- 0.0 mm (FWHM), respectively. With the addition of TOF, the mCT also produced substantially higher image contrast recovery and signal-to-noise ratios in a clinically-relevant phantom geometry. The benefits of TOF were clearly demonstrated in representative patient images.
机译：飞行时间（TOF）测量功能有望改善PET图像质量。我们将其第一款Biograph mCT TOF PET / CT扫描仪（美国西门子医疗解决方案有限公司）与其前身Biograph TruePoint TrueV进行了物理和临床PET性能比较。特别是，我们定义了TOF的改进。根据美国国家电气制造商协会（NEMA）NU 2-2007标准对物理性能进行了评估，并进行了其他测量以专门解决TOF能力。分析患者数据以获得扫描仪的临床性能。正如对相同大小的晶体检测器所期望的那样，在mCT上测得的空间分辨率与TruePoint TrueV相似。 mCT表现出适度较高的灵敏度（增加了19.7 +/- 2.8％）和峰值噪声当量计数率（NECR）（增加了15.5 +/- 5.7％），且散射分数相似。高达55 Mcps的变化单计数率的能量，时间和空间分辨率导致11.5 +/- 0.2％（FWHM），527.5 +/- 4.9 ps（FWHM）和4.1 +/- 0.0 mm（FWHM），分别。随着TOF的加入，mCT在与临床相关的幻像几何体中还产生了显着更高的图像对比度恢复和信噪比。在代表性的患者图像中清楚地证明了TOF的好处。

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